Abstract

Public Health Relevance

The Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) is a devastating consequence of systemic inflammatory conditions (such as sepsis) that afflicts an estimated 200,000 people a year in the US with 75,000 deaths. No specific therapy is available to target the underlying mechanistic causes of this syndrome. This proposal seeks to evaluate the potential therapeutic effectiveness of novel FTY720 analogues in models of this disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL098050-01A1
Application #
8114297
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
1
Fiscal Year
2011
Total Cost
$428,537
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Fu, Panfeng; Ebenezer, David L; Ha, Alison W et al. (2018) Nuclear lipid mediators: Role of nuclear sphingolipids and sphingosine-1-phosphate signaling in epigenetic regulation of inflammation and gene expression. J Cell Biochem 119:6337-6353
Natarajan, Viswanathan; Ha, Alison W; Dong, Yangbasai et al. (2017) Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. BMC Genomics 18:664
Ebenezer, David L; Fu, Panfeng; Suryadevara, Vidyani et al. (2017) Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. Adv Biol Regul 63:156-166
Rizzo, Alicia N; Dudek, Steven M (2017) Endothelial Glycocalyx Repair: Building a Wall to Protect the Lung during Sepsis. Am J Respir Cell Mol Biol 56:687-688
Huang, Long Shuang; Jiang, Peiyue; Feghali-Bostwick, Carol et al. (2017) Lysocardiolipin acyltransferase regulates TGF-? mediated lung fibroblast differentiation. Free Radic Biol Med 112:162-173
Ebenezer, David L; Fu, Panfeng; Natarajan, Viswanathan (2016) Targeting sphingosine-1-phosphate signaling in lung diseases. Pharmacol Ther 168:143-157
Harijith, Anantha; Pendyala, Srikanth; Ebenezer, David L et al. (2016) Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. Am J Physiol Lung Cell Mol Physiol 311:L337-51
Viswanathan, P; Ephstein, Y; Garcia, J G N et al. (2016) Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. Biochem Biophys Res Commun 478:599-605
Xie, Lishi; Chiang, Eddie T; Wu, Xiaomin et al. (2016) Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. PLoS One 11:e0158865
Ackerman, Steven J; Park, Gye Young; Christman, John W et al. (2016) Polyunsaturated lysophosphatidic acid as a potential asthma biomarker. Biomark Med 10:123-35

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