Abstract

Core A of the Program Project will reside in the Department of Physiology and Biophysics of the Albert Einstein College of Medicine which is the academic home of the Principal Investigator, Joel Friedman and the applicant institution. The chairman of the Department, Professor Denis Rousseau, is fully supportive of this program and will also be a member of the Internal Advisory Board. Albert Einstein College of Medicine is headed by the Dean, Professor Alan Spiegel. The Dean is also very supportive of the program and has committed additional funds for instruments in the event the PPG is funded (see attached letter). The administrative office of Core A consists of three components: i) The Pi's office;ii) a small adjacent office for the administrative secretary;and iii) the administrative office of the Pi's department (Physiology and Biophysics) which is located on the same floor and doors down from the Pi's office.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL110900-03
Application #
8707844
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
3
Fiscal Year
2014
Total Cost
$131,695
Indirect Cost
$49,419

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Kettisen, Karin; Strader, Michael Brad; Wood, Francine et al. (2018) Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin. Redox Biol 19:218-225
Alayash, Abdu I (2018) Oxidative pathways in the sickle cell and beyond. Blood Cells Mol Dis 70:78-86
Wallace, Martina; Green, Courtney R; Roberts, Lindsay S et al. (2018) Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol 14:1021-1031
Sjodt, Megan; Macdonald, Ramsay; Marshall, Joanna D et al. (2018) Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus. J Biol Chem 293:6942-6957
Jana, Sirsendu; Strader, Michael Brad; Meng, Fantao et al. (2018) Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles. JCI Insight 3:
Kassa, Tigist; Strader, M B; Nakagawa, Akito et al. (2017) Targeting ?Cys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects. Metallomics 9:1260-1270
Martucci, Alexandre Fabricio; Abreu Martucci, Ana Carolina Carvalho Ferreira; Cabrales, Pedro et al. (2017) Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol 45:24-30
Jana, Sirsendu; Meng, Fantao; Hirsch, Rhoda E et al. (2017) Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells. Front Physiol 8:1082
Cardenas, Andres S Benitez; Samuel, Premila P; Olson, John S (2017) 2017 Military Supplement: Current Challenges in the Development of Acellular Hemoglobin Oxygen Carriers by Protein Engineering. Shock :
Ao-Ieong, Eilleen S Y; Williams, Alexander; Jani, Vivek et al. (2017) Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic. Artif Cells Nanomed Biotechnol 45:686-693

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