The Administrative Core will provide support for each of the five Projects as well as the Scientific Core.
The Aims of this Administrative Core are to ensure that the resources within the PPG are distributed equitably amongst the investigators, and that all the rules and regulations of the National Heart Lung and Blood Institute and the National Institute of Health are followed precisely. The Administrative Core will coordinate monthly meetings of the investigators and their laboratories, and will facilitate communication with both the Internal and External Advisory Boards. Ms. Michele Arlotta, Business Administrator of the Hematology/Oncology Division of the University of Pennsylvania School of Medicine, will organize the finances of the PPG. She will meet monthly with the PPG Principal Investigator, and quarterly with each Project and Core leader. Ms. Terese Manganaro will coordinate travel arrangements for the members of the PPG, as well as for the Advisors of the PPG who will visit Penn. For each PPG Investigator, she will also provide administrative support for their efforts related to the Program Project. It is anticipated that through the combined efforts of the Administrative Core Director (Dr. Abrams), Ms. Arlotta, and Ms. Manganaro, that the research performed by the individual Projects within the PPG will run more efficiently. Every effort was made to minimize the cost of this Administrative Core to maximize the funds available for the scientific goals of the Program.

Public Health Relevance

CORE A - NARRATIVE Platelet and coagulation factors play a role not only in the prevention of bleeding, but also in the development of heart attacks and strokes. This Program Project is focused on developing a better understanding of platelets and coagulation. The Administrative Core will support the researchers while they work to achieve this goal.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL120846-01A1
Application #
8742307
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-08-08
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$55,999
Indirect Cost
$20,999
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mirramezani, M; Herbig, B A; Stalker, T J et al. (2018) Platelet packing density is an independent regulator of the hemostatic response to injury. J Thromb Haemost 16:973-983
Capitano, Maegan; Zhao, Liang; Cooper, Scott et al. (2018) Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-?1 secretion and hematopoiesis in mice. Blood 132:1027-1038
Branchford, B R; Stalker, T J; Law, L et al. (2018) The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis. J Thromb Haemost 16:352-363
Bergmeier, Wolfgang; Stefanini, Lucia (2018) Platelets at the Vascular Interface. Res Pract Thromb Haemost 2:27-33
Zhao, Baobing; Mei, Yang; Cao, Lan et al. (2018) Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest 128:125-140
Yago, Tadayuki; Zhang, Nan; Zhao, Liang et al. (2018) Selectins and chemokines use shared and distinct signals to activate ?2 integrins in neutrophils. Blood Adv 2:731-744
Stefanini, L; Bergmeier, W (2018) Negative regulators of platelet activation and adhesion. J Thromb Haemost 16:220-230
Xie, Zhigang; Hur, Seong Kwon; Zhao, Liang et al. (2018) A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Dev Cell 44:725-740.e4
Shen, Jian; Sampietro, Sara; Wu, Jie et al. (2017) Coordination of platelet agonist signaling during the hemostatic response in vivo. Blood Adv 1:2767-2775
Kononova, Olga; Litvinov, Rustem I; Blokhin, Dmitry S et al. (2017) Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin ?IIb?3. Biochemistry 56:1932-1942

Showing the most recent 10 out of 52 publications