A multidisciplinary collaborative research effort bringing new knowledge, concepts and techniques from fundamental disciplines to bear on the problem of schizophrenia and other major psychoses. The disciplines represented as major components of the program are neuroanatomy, neuropathology, genetics, neuropharmacology, psychology and clinical investigations. Research in neuroanatomy will continue to examine by anterograde- and retrograde-labelling the position of the monoamine cell groups in the overall organization of the fore- and mid-brain. A novel approach to neuropathology will utilize computer-assisted morphometric techniques for quantitative analysis of dendrite arborizations of neurons. Genetic studies will examine questions of nosology, etiology diversity, genetic and environmental factors utilizing adopted individuals and their relatives, or by the intensive study of families with a high frequency of mental disorder. Pharmacological studies will examine specific behavioral responses of the neuroleptic drugs, their diurnal rhythms, and alterations associated with estrus, pregnancy, development and aging. Psychological studies will examine smooth pursuit and saccadic eye movements, the nature of the cognitive disorder and of information processing in schizophrenic and control populations. Studies with a radioreceptor assay for neuroleptics, therapeutic approaches based on new rationales, and the development of rigorous diagnostic concepts and their epidemiological application will constitute the focus of the clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH031154-12
Application #
3099022
Study Section
(TDAC)
Project Start
1977-08-01
Project End
1991-11-30
Budget Start
1989-01-01
Budget End
1989-11-30
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
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Deutsch, Curtis K; Levy, Deborah L; Price, Selya F R et al. (2015) Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness. Schizophr Bull 41:1309-16
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Ma, Jianyi; Ye, Nancy; Cohen, Bruce M (2006) Expression of noradrenergic alpha1, serotoninergic 5HT2a and dopaminergic D2 receptors on neurons activated by typical and atypical antipsychotic drugs. Prog Neuropsychopharmacol Biol Psychiatry 30:647-57
Chen, Yue; Bidwell, L Cinnamon; Holzman, Philip S (2005) Visual motion integration in schizophrenia patients, their first-degree relatives, and patients with bipolar disorder. Schizophr Res 74:271-81

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