Abstract

This is an application for a NEUROSCIENCE WORK GROUP IN MENTAL HEALTH that will bring together eleven senior investigators for collaborative research on the neurohormonal mechanisms of salt appetite in the rat. Recent behavioral-endocrinological research has demonstrated that salt appetite is an hormonally induced behavior. It is aroused by the synergistic action in the brain of angiotensin and aldosterone which are also the hormones of renal sodium conservation. The Work Group will combine behavioral- endocrinological methods with state-of-the-art biological techniques (cytosol receptor analysis, membrane pharmacology, microiontophoresis and electrophysiology, and cellular biochemistry) in a broad-ranging reductionist analysis of the neural mechanisms by which angiotensin and aldosterone act to arouse a specific motivated behavior that depends for its expression on a single sensory channel (the salt taste). Six Projects are proposed. They are closely integrated around the central question: What is the cellular and molecular nature of the neural mechanism by which angiotensin and associated hormones (aldosterone and atrial natriuretic hormone) mobilize salt. appetite?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH043787-04
Application #
3099093
Study Section
Special Emphasis Panel (SRCM (01))
Project Start
1989-02-01
Project End
1993-11-30
Budget Start
1992-05-01
Budget End
1992-11-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Lucas, Louis R; Grillo, Claudia A; McEwen, Bruce S (2007) Salt appetite in sodium-depleted or sodium-replete conditions: possible role of opioid receptors. Neuroendocrinology 85:139-47
Sakai, Randall R (2004) The future of research on thirst and salt appetite. Appetite 42:15-9
Daniels, Derek; Fluharty, Steven J (2004) Salt appetite: a neurohormonal viewpoint. Physiol Behav 81:319-37
Lundy Jr, Robert F; Caloiero, Vince; Bradley, Courtney et al. (2004) Furosemide-induced food avoidance: evidence for a conditioned response. Physiol Behav 81:397-408
Lucas, Louis R; Grillo, Claudia A; McEwen, Bruce S (2003) Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses. Neuroendocrinology 77:406-15
Fitts, Douglas A; Thornton, Simon N; Ruhf, Alexandra A et al. (2003) Effects of central oxytocin receptor blockade on water and saline intake, mean arterial pressure, and c-Fos expression in rats. Am J Physiol Regul Integr Comp Physiol 285:R1331-9
Hines, John; Fluharty, Steven J; Yee, Daniel K (2003) Structural determinants for the activation mechanism of the angiotensin II type 1 receptor differ for phosphoinositide hydrolysis and mitogen-activated protein kinase pathways. Biochem Pharmacol 66:251-62
Tamura, R; Norgren, R (2003) Intracranial renin alters gustatory neural responses in the nucleus of the solitary tract of rats. Am J Physiol Regul Integr Comp Physiol 284:R1108-18
Lucas, Louis R; Reagan, Lawrence P; Akama, Keith T et al. (2003) Decreases in neurokinin-3 tachykinin receptor-immunoreactive and -mRNA levels are associated with salt appetite in the deoxycorticosterone-treated rat. Brain Res 960:252-8
Bello, Nicholas T; Lucas, Louis R; Hajnal, Andras (2002) Repeated sucrose access influences dopamine D2 receptor density in the striatum. Neuroreport 13:1575-8

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