Abstract

Project 4 proposes to examine whether exposure of the human fetal CNS to HIV-1 may cause alterations in normal myelination. These changes may be a part of the basis for the neurologic dysfunction characteristic of pediatric AIDS. A 3-part research protocol has been designed to test this hypothesis: the first component will examine myelination qualitatively and quantitatively in fetal CNS tissue exposed to HIV-1 in utero; the second part of this study will use an in vitro organotypic explant model of human fetal CNS cells and focus on oligodendrocyte differentiation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
5P01MH047667-02
Application #
3860660
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Grever, W E; Weidenheim, K M; Tricoche, M et al. (1997) Oligodendrocyte gene expression in the human fetal spinal cord during the second trimester of gestation. J Neurosci Res 47:332-40
Gilles, J M; Divon, M Y; Bentolila, E et al. (1997) Immunophenotypic characterization of human fetal liver hematopoietic stem cells during the midtrimester of gestation. Am J Obstet Gynecol 177:619-25
Chan, S O; Lyman, W D; Chiu, F C (1997) Temporal and spatial expression of glutamic acid decarboxylases in human fetal brain. Brain Res Mol Brain Res 46:318-20
Makman, M H; Lyman, W D; Dvorkin, B (1997) Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus. Brain Res 762:247-50
Cajigas, A; Suhrland, M; Harris, C et al. (1997) Correlation of the ratio of CD4+/CD8+ cells in lymph node fine needle aspiration biopsies with HIV clinical status. A preliminary study. Acta Cytol 41:1762-8
Grever, W E; Chiu, F C; Tricoche, M et al. (1996) Quantification of myelin basic protein in the human fetal spinal cord during the midtrimester of gestation. J Comp Neurol 376:306-14
Weidenheim, K M; Bodhireddy, S R; Rashbaum, W K et al. (1996) Temporal and spatial expression of major myelin proteins in the human fetal spinal cord during the second trimester. J Neuropathol Exp Neurol 55:734-45
Dickson, D W; Lee, S C (1996) Microglia in HIV-related CNS neuropathology: an update. J NeuroAIDS 1:57-83
Lee, S C; Dickson, D W; Casadevall, A (1996) Pathology of cryptococcal meningoencephalitis: analysis of 27 patients with pathogenetic implications. Hum Pathol 27:839-47
Aquino, D A; Padin, C; Perez, J M et al. (1996) Analysis of glial fibrillary acidic protein, neurofilament protein, actin and heat shock proteins in human fetal brain during the second trimester. Brain Res Dev Brain Res 91:1-10

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