Abstract

We plan to assess trait-markers for the development and course of depressive disorders, we propose to study individuals who were identified and diagnosed with depressive disorders in childhood, their offspring, and the adult siblings of the depressed probands; individuals who were identified and diagnosed with anxiety disorders in childhood and their offspring; and subjects with no history of child/adolescent psychiatric illness and their offspring. Assessments include baseline studies of central and autonomic nervous system functioning; studies of affect regulation; and studies of the startle response in selected subjects. Measures include brain electrical activity (EEG), autonomic nervous system activity (heart rate and vagal tone), facial electromyographic activity (EMG), emotion expression, trait emotion, and (in children) internalizing and externalizing problems. The Scheduling and Psychiatric Evaluation Core of the Program Project will assess psychiatric disorder, dates of onset and remission, and symptom severity ratings. We will test the hypothesis that depressive and anxiety disorders are associated with differential patterns of physiologic, behavioral, and emotional response; and individual differences in these patterns are associated with course and severity of disorder.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Program Projects (P01)
Project #
1P01MH056193-01A1
Application #
6243318
Study Section
Project Start
1997-08-01
Project End
1998-07-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Nusslock, Robin; Shackman, Alexander J; McMenamin, Brenton W et al. (2018) Comorbid anxiety moderates the relationship between depression history and prefrontal EEG asymmetry. Psychophysiology 55:
Panaite, Vanessa; Bylsma, Lauren M; Kovacs, Maria et al. (2018) Dysregulated behavioral responses to hedonic probes among youth with depression histories and their high-risk siblings. Emotion :
Kovacs, Maria; Lopez-Duran, Nestor L; George, Charles et al. (2017) The Development of Mood Repair Response Repertories: I. Age-Related Changes Among 7- to 14-Year-Old Depressed and Control Children and Adolescents. J Clin Child Adolesc Psychol :1-10
Daches, Shimrit; Kovacs, Maria; George, Charles J et al. (2017) Childhood adversity predicts reduced physiological flexibility during the processing of negative affect among adolescents with major depression histories. Int J Psychophysiol 121:22-28
Kovacs, Maria; Obrosky, Scott; George, Charles (2016) The course of major depressive disorder from childhood to young adulthood: Recovery and recurrence in a longitudinal observational study. J Affect Disord 203:374-381
Yaroslavsky, Ilya; Rottenberg, Jonathan; Bylsma, Lauren M et al. (2016) Parasympathetic nervous system activity predicts mood repair use and its effectiveness among adolescents with and without histories of major depression. J Abnorm Psychol 125:323-36
Kovacs, Maria; Bylsma, Lauren M; Yaroslavsky, Ilya et al. (2016) Positive Affectivity is Dampened in Youths with Histories of Major Depression and Their Never-Depressed Adolescent Siblings. Clin Psychol Sci 4:661-674
Bylsma, Lauren M; Yaroslavsky, Ilya; Rottenberg, Jonathan et al. (2016) Familiality of mood repair responses among youth with and without histories of depression. Cogn Emot 30:807-16
Kovacs, Maria; Yaroslavsky, Ilya; Rottenberg, Jonathan et al. (2015) Mood repair via attention refocusing or recall of positive autobiographical memories by adolescents with pediatric-onset major depression. J Child Psychol Psychiatry 56:1108-17
Rimay, Timea; Benak, Istvan; Kiss, Eniko et al. (2015) BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression. Psychiatr Genet 25:249-55

Showing the most recent 10 out of 93 publications