Abstract

The purpose of Core E is to: a) provide quantitative analyses of the behavioral correlates of cerebral ischemia in animal models; b) assess long-term recovery of function following ischemia; and c) evaluate therapeutic strategies for treatment of cerebral ischemia using behavioral outcomes. In each case, behavioral measures will be correlated with morphological sequelae of cerebral ischemia (see Projects 1-4). Behavioral paradigms were designed to assess functional deficits associated with three different animal models of cerebral ischemia: 1) photochemical infarction of the somatosensory cortex in rats (see Project 2); 2) global cerebral ischemia induce by either 2-vessel or 4-vessel occlusion in rats (see Projects 3 & 4 and Core C-1); and 3) brain injury resulting from occlusion of the middle cerebral artery in rats (see Project 1).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS005820-32
Application #
6243366
Study Section
Project Start
1997-06-01
Project End
1998-05-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
32
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Dave, Kunjan R; Della-Morte, David; Saul, Isabel et al. (2013) Ventricular fibrillation-induced cardiac arrest in the rat as a model of global cerebral ischemia. Transl Stroke Res 4:571-8
Della-Morte, D; Raval, A P; Dave, K R et al. (2011) Post-ischemic activation of protein kinase C ? protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow. Neurosci Lett 487:158-62
Dave, Kunjan R; Anthony Defazio, Richard; Raval, Ami P et al. (2009) Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel. J Neurochem 110:1170-9
DeFazio, R Anthony; Raval, Ami P; Lin, Hung W et al. (2009) GABA synapses mediate neuroprotection after ischemic and epsilonPKC preconditioning in rat hippocampal slice cultures. J Cereb Blood Flow Metab 29:375-84
Della-Morte, D; Dave, K R; DeFazio, R A et al. (2009) Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 159:993-1002
Park, Hee-Pyoung; Nimmagadda, Anitha; DeFazio, Richard A et al. (2008) Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy study. Stroke 39:1556-62
Dave, Kunjan R; DeFazio, R Anthony; Raval, Ami P et al. (2008) Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon. J Neurosci 28:4172-82
Kim, Eun J; Raval, Ami P; Perez-Pinzon, Miguel A (2008) Preconditioning mediated by sublethal oxygen-glucose deprivation-induced cyclooxygenase-2 expression via the signal transducers and activators of transcription 3 phosphorylation. J Cereb Blood Flow Metab 28:1329-40
Nimmagadda, Anitha; Park, Hee-Pyoung; Prado, Ricardo et al. (2008) Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laser-scanning microscopy study. Stroke 39:198-204
Kim, E; Raval, A P; Defazio, R A et al. (2007) Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro. Neuroscience 145:931-41

Showing the most recent 10 out of 15 publications