The CORE represents one of the unifying aspects of our Progam Project Grant (NS13742-29). We have had such a facility since the inception of our Program Project. The following main goals have and will continue to justify the support of a Machine Shop CORE over the last twenty-seven years: (1) The CORE facility has supported the development and/or the application, of a new technology to construct mor modify instruments (e.g., two-photon microscopy) at a fraction of the cost commercially, as well as the development of specilized equipment not available commercially. (2) The maintenance of electronic, mechanical and optical systems of our Program Project group. (3) Development of hardware models based on the biological neuroscience findings supported by this grant. For example, the development of the inferior olive (IO) neuron chip for the motor control system that tests the role of IO in motor coordination. (4) Development and maintenance of computer systems and the development of specialized software to be used in electrophysiological and optical imaging. (5) Storage and ordering of mechanical and electronic parts required in the running of the Program Project research protocols. The CORE represents one of the unifying aspects of our Progam Project Grant (NS13742-29). We have had such a facility since the inception of our Program Project. The following main goals have and will continue to justify the support of a Machine Shop CORE over the last twenty-seven years: (1) The CORE facility has supported the development and/or the application, of a new technology to construct mor modify instruments (e.g., two-photon microscopy) at a fraction of the cost commercially, as
| Choi, Soonwook; Yu, Eunah; Hwang, Eunjin et al. (2016) Pathophysiological implication of CaV3.1 T-type Ca2+ channels in trigeminal neuropathic pain. Proc Natl Acad Sci U S A 113:2270-5 |
| Choi, Soonwook; Yu, Eunah; Lee, Seongwon et al. (2015) Altered thalamocortical rhythmicity and connectivity in mice lacking CaV3.1 T-type Ca2+ channels in unconsciousness. Proc Natl Acad Sci U S A 112:7839-44 |
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| Hensbroek, Robert A; Belton, Tim; van Beugen, Boeke J et al. (2014) Identifying Purkinje cells using only their spontaneous simple spike activity. J Neurosci Methods 232:173-80 |
| Ivannikov, Maxim V; Sugimori, Mutsuyuki; Llinás, Rodolfo R (2013) Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume. J Mol Neurosci 49:223-30 |
| Chagnaud, Boris P; Zee, Michele C; Baker, Robert et al. (2012) Innovations in motoneuron synchrony drive rapid temporal modulations in vertebrate acoustic signaling. J Neurophysiol 107:3528-42 |
| Simpson, John I (2011) Crossing zones in the vestibulocerebellum: a commentary. Cerebellum 10:515-22 |
| Chagnaud, Boris P; Baker, Robert; Bass, Andrew H (2011) Vocalization frequency and duration are coded in separate hindbrain nuclei. Nat Commun 2:346 |
| Park, Young-Gyun; Park, Hye-Yeon; Lee, C Justin et al. (2010) Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive. Proc Natl Acad Sci U S A 107:10731-6 |
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