By means of emission computed tomography of patients, we will quantify and localize cerebral biochemical patterns in order to explore the mechanisms underlying human epilepsy, behavior disorders, and other neurological abnormalities. Local cerebral glucose metabolism will be measured by scanning after intravenous injection of F-18-fluorodeoxyglucose. The feasibility will be tested for in vivo receptor assays in man based on emission computed tomography of positron emitter labeled radioligands. Parallel studies will be carried out using quantitative autoradiography of C-14-deoxyglucose and other agents in suitable animal models.
| Engel Jr, Jerome (2016) When is temporal lobe epilepsy not temporal lobe epilepsy? Brain 139:309-12 |
| Engel Jr, Jerome (2015) Who will use epilepsy surgery nomograms, and why? Lancet Neurol 14:240-1 |
| Engel Jr, Jerome; Dichter, Marc A (2014) Epilepsy. Foreword. Adv Exp Med Biol 813:v-xiii |
| Pitkänen, Asla; Engel Jr, Jerome (2014) Past and present definitions of epileptogenesis and its biomarkers. Neurotherapeutics 11:231-41 |
| Engel Jr, Jerome; da Silva, Fernando Lopes (2012) High-frequency oscillations - where we are and where we need to go. Prog Neurobiol 98:316-8 |
| Engel Jr, Jerome; Wiebe, Samuel (2012) Who is a surgical candidate? Handb Clin Neurol 108:821-8 |
| Engel Jr, Jerome (2011) Biomarkers in epilepsy: introduction. Biomark Med 5:537-44 |
| Villablanca, Jaime R (2010) Why do we have a caudate nucleus? Acta Neurobiol Exp (Wars) 70:95-105 |
| Engel Jr, Jerome; Akhtari, Massoud; Bragin, Anatol et al. (2010) New approaches to structural and functional imaging in focal epilepsy. Epilepsia 51 Suppl 1:83-6 |
| Engel Jr, Jerome (2008) Progress in epilepsy: reducing the treatment gap and the promise of biomarkers. Curr Opin Neurol 21:150-4 |
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