CORECCLINICAL ASSESSMENTThe Program Project Grant (PPG) Clinical Assessment Core provides the organizational structure andoperations oversight for recruiting normal controls and subjects with Parkinson Disease (PD). AppropriatePD subjects will be referred to the PPG Clinical Assessment Core from four sites: the Movement DisordersClinics (MvtDCs) in the Department of Neurology at the University of Michigan (DM), the Ann Arbor VA,Medical University of Ohio (MUO), and Michigan State University (MSU). Control subjects will be referredfrom the Michigan Alzheimer's Disease Center (MADRC) and the UM Claude D. Pepper Older AmericansIndependence Center (OAIC). Subject-initiated recruitment will be provided via the Michigan ParkinsonFoundation and the web-based UM Engage research subject registry.The Clinical Assessment Core will provide central recruiting and standardized assessments for allprojects in this PPG. The core will provide an organizational structure and integration for subjectcharacterization with standardized clinical, motor, neurobehavioral/neuropsychiatric, and neuropsychologicalassessments. The Core will also organize standard imaging for all subjects consisting of brain MRI, andDTBZ and PMP PET imaging. Longitudinal evaluations will be organized for projects 1 and 4. The Core willhave diagnostic consensus conferences where cases are discussed and diagnoses assigned; follow-upcases are reviewed for diagnostic reasessment. The Core will also provide the logistic organization for bloodsampling for DMA banking (off-site) and assist with brain bank referrals. The PPG Clinical Assessment Corewill have a standardized method for data collection, entry and verification and will transfer data to theTomography and Data Analysis Core (Core B) for analysis.
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