Each of the projects within this program acquire data which can be better understood through the use of complex computer and/or image analysis. The core also will be responsible for the acquisition of MRI data collected as part of Project 0010. The combined efforts of the personnel in the projects and within the core will provide a critical mass to help insure that all data are collected efficiently and accurately, analyzed appropriately and displayed or communicated most effectively. A biostatistician will monitor and supervise the statistical aspects of each project. The functions of the Core unit can be divided logically into three separate and distinct phases; acquisition, analysis and visualization. This core will interact with investigators to assist in all three phases of data treatment. The core will function to augment existing capabilities within the investigators' laboratories as well as to provide resources that would otherwise be unavailable to individual projects. The specific objectives of the Computer Core are to provide support and expertise for the following functions: 1) the analysis of time series data such as EMG, kinematic and force records, essential to both the cat and the human locomotion projects (Projects II and III); 2) the 3-dimensional reconstruction of motor units in selected cat muscles (Project I); and 3) the 3-dimensional reconstruction and calculation of volumes in normal and atrophied muscles (Project III). The research activities of this core will be devoted to the development of software to improve data acquisition, analyses and visualization. To facilitate this function and to aid in the communication among the projects the entire core as well as each individual project will be connected through a campus wide fiber optic network.

Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Duru, Paul O; Tillakaratne, Niranjala J K; Kim, Jung A et al. (2015) Spinal neuronal activation during locomotor-like activity enabled by epidural stimulation and 5-hydroxytryptamine agonists in spinal rats. J Neurosci Res 93:1229-39
Tillakaratne, Niranjala J K; Duru, Paul; Fujino, Hidemi et al. (2014) Identification of interneurons activated at different inclines during treadmill locomotion in adult rats. J Neurosci Res 92:1714-22
Terson de Paleville, Daniela; McKay, William; Aslan, Sevda et al. (2013) Locomotor step training with body weight support improves respiratory motor function in individuals with chronic spinal cord injury. Respir Physiol Neurobiol 189:491-7
Johnson, Will L; Jindrich, Devin L; Roy, Roland R et al. (2012) Quantitative metrics of spinal cord injury recovery in the rat using motion capture, electromyography and ground reaction force measurement. J Neurosci Methods 206:65-72
Harkema, Susan; Behrman, Andrea; Barbeau, Hugues (2012) Evidence-based therapy for recovery of function after spinal cord injury. Handb Clin Neurol 109:259-74
Johnson, Will L; Jindrich, Devin L; Zhong, Hui et al. (2011) Application of a rat hindlimb model: a prediction of force spaces reachable through stimulation of nerve fascicles. IEEE Trans Biomed Eng 58:3328-38
Roy, Roland R; Zhong, Hui; Monti, Ryan J et al. (2011) Selectively reshaping a muscle phenotype: functional overload of cat plantaris. Muscle Nerve 43:489-99
Ichiyama, Ronaldo M; Broman, Jonas; Roy, Roland R et al. (2011) Locomotor training maintains normal inhibitory influence on both alpha- and gamma-motoneurons after neonatal spinal cord transection. J Neurosci 31:26-33
Joseph, M Selvan; Bilousova, Tina; Zdunowski, Sharon et al. (2011) Transgenic Mice With Enhanced Neuronal Major Histocompatibility Complex Class I Expression Recover Locomotor Function Better After Spinal Cord Injury. J Neurosci 89:365-372
Kim, Jung A; Roy, Roland R; Kim, Soo J et al. (2010) Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles. Muscle Nerve 42:410-21

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