The goal of this project is to determine whether there exist chronic alterations in blood composition which are linked to blood hyperviscosity and recurrent stroke. Evidence from cross sectional measurements indicates that low serum albumin and elevations in fibrinogen, leucocytes, and blood viscosity are interrelated, but the duration of these alterations and their relationship to stroke recurrence are not known. Several lines of both clinical and biochemical evidence suggest that impaired glucose tolerance contributes to blood hyperviscosity. Interleukins 1 and 6, by regulating fibrinogen and albumin biosynthesis, are likewise thought to contribute to viscous abnormalities.
The specific aims of this proposal will test the hypotheses that 1) chronic blood hyperviscosity exists and contributes to recurrent stroke; 2) impaired glucose tolerance contributes to hyperviscosity; 3) interleukins 1 and 6 are humoral mediators of hyperviscosity; and 4) hyperviscosity variables may be improved with treatment. The evaluate these hypotheses a longitudinal study of subjects grouped according to the presence or absence of hyperviscosity will be conducted. The incidence of the clinical endpoints of recurrent stroke, myocardial infarction, and vascular death in the two groups will be compared. Longitudinal measurements of whole blood, plasma, and serum viscosity, glycated hemoglobin, and urinary microalbumin will be made, and in pilot studies interleukins 1 and 6 and plasma free insulin will be measured.

Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Seil, Fredrick J (2014) The changeable nervous system: studies on neuroplasticity in cerebellar cultures. Neurosci Biobehav Rev 45:212-32
Clark, W M; Hazel, J S; Coull, B M (1995) Lazaroids. CNS pharmacology and current research. Drugs 50:971-83
Clark, W M; Lauten, J D; Lessov, N et al. (1995) The influence of antiadhesion therapies on leukocyte subset accumulation in central nervous system ischemia in rats. J Mol Neurosci 6:43-50
Clark, W M; Lauten, J D; Lessov, N et al. (1995) Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol Chem Neuropathol 26:213-30
Clark, W M; Hotan, T; Lauten, J D et al. (1994) Therapeutic efficacy of tirilazad in experimental multiple cerebral emboli: a randomized, controlled trial. Crit Care Med 22:1161-6
Clark, W M; Calcagno, F A; Gabler, W L et al. (1994) Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment. Stroke 25:1411-5;discussion 1416
Clark, W M; Coull, B M; Briley, D P et al. (1993) Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. J Neuroimmunol 44:123-5
Coull, B M; Clark, W M (1993) Abnormalities of hemostasis in ischemic stroke. Med Clin North Am 77:77-94
Clark, W M; Coull, B M; Beamer, N B (1993) Need for treatment of elevated plasma fibrinogen levels in cerebrovascular disease. Heart Dis Stroke 2:503-6
Coull, B M; Levine, S R; Brey, R L (1992) The role of antiphospholipid antibodies in stroke. Neurol Clin 10:125-43

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