Abstract

The primary focus of the proposed research will be to study the biological basis of implicit memory function. Specifically, patients with unilateral neocortical lesions will be assessed on a variety of implicit memory tests. Subjects will include patients with dorsolateral prefrontal lesions, patients with temporal-parietal lesions, and patients with occipital lesions. Various tests of implicit memory (e.g., tests of perceptual, lexical, and semantic priming) and various stimulus material (e.g., verbal, nonverbal) will be used to determine patterns of impairment on these tests in patients with neocortical lesions. It is predicted that secondary sensory areas (e.g., prestriate occipital areas) will be critical for perceptual priming, temporal-parietal associational areas will be critical for lexical priming, and frontal areas will be critical for semantic priming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS017778-15
Application #
5215148
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Shimamura, Arthur P; Marian, Diane E; Haskins, Andrew L (2013) Neural correlates of emotional regulation while viewing films. Brain Imaging Behav 7:77-84
Shimamura, Arthur P (2010) Hierarchical relational binding in the medial temporal lobe: the strong get stronger. Hippocampus 20:1206-16
Shimamura, Arthur P; Wickens, Thomas D (2009) Superadditive memory strength for item and source recognition: the role of hierarchical relational binding in the medial temporal lobe. Psychol Rev 116:1-19
Miller, Michael B; Donovan, Christa-Lynn; Van Horn, John D et al. (2009) Unique and persistent individual patterns of brain activity across different memory retrieval tasks. Neuroimage 48:625-35
Mullette-Gillman, O'Dhaniel A; Cohen, Yale E; Groh, Jennifer M (2009) Motor-related signals in the intraparietal cortex encode locations in a hybrid, rather than eye-centered reference frame. Cereb Cortex 19:1761-75
Turken, Andu; Whitfield-Gabrieli, Susan; Bammer, Roland et al. (2008) Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies. Neuroimage 42:1032-44
Saygin, Ayse Pinar; Wilson, Stephen M; Dronkers, Nina F et al. (2004) Action comprehension in aphasia: linguistic and non-linguistic deficits and their lesion correlates. Neuropsychologia 42:1788-804
Bates, Elizabeth; Wilson, Stephen M; Saygin, Ayse Pinar et al. (2003) Voxel-based lesion-symptom mapping. Nat Neurosci 6:448-50
Stone, Valerie E; Cosmides, Leda; Tooby, John et al. (2002) Selective impairment of reasoning about social exchange in a patient with bilateral limbic system damage. Proc Natl Acad Sci U S A 99:11531-6
Eliassen, J C; Baynes, K; Gazzaniga, M S (2000) Anterior and posterior callosal contributions to simultaneous bimanual movements of the hands and fingers. Brain 123 Pt 12:2501-11

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