Abstract

The function of this core is to provide Neuropathological expertise to the investigators in each of the projects. Dr. Weiner is the director of the core and will interact with all the investigators in a collaborative manner and provide expert Neuropathological assistance with their experiments and as an overall resource person. Projects will provide experimental animal tissues or tissue culture specimens for the assessment of neuropathology and special immunocytochemical studies. This core will also provide primary neural cultures derived from normal and experimental animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS018146-16
Application #
6243525
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
16
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Kapil, Parul; Butchi, Niranjan B; Stohlman, Stephen A et al. (2012) Oligodendroglia are limited in type I interferon induction and responsiveness in vivo. Glia 60:1555-66
Savarin, Carine; Stohlman, Stephen A; Rietsch, Anna M et al. (2011) MMP9 deficiency does not decrease blood-brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitis. Glia 59:1770-81
Savarin, Carine; Stohlman, Stephen A; Atkinson, Roscoe et al. (2010) Monocytes regulate T cell migration through the glia limitans during acute viral encephalitis. J Virol 84:4878-88
Phares, Timothy W; Stohlman, Stephen A; Hinton, David R et al. (2010) Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol 185:5607-18
Phares, Timothy W; Ramakrishna, Chandran; Parra, Gabriel I et al. (2009) Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol 182:5430-8
Zuo, Jun; Stohlman, Stephen A; Parra, Gabriel I et al. (2009) IL-15 independent maintenance of virus-specific CD8(+) T cells in the CNS during chronic infection. J Neuroimmunol 207:32-8
Savarin, Carine; Bergmann, Cornelia C (2008) Neuroimmunology of central nervous system viral infections: the cells, molecules and mechanisms involved. Curr Opin Pharmacol 8:472-9
Stohlman, S A; Hinton, D R (2001) Viral induced demyelination. Brain Pathol 11:92-106
Stohlman, S A; Bergmann, C; Cua, D et al. (1994) Location of antibody epitopes within the mouse hepatitis virus nucleocapsid protein. Virology 202:146-53
Strong, R K; Penny, D M; Feldman, R M et al. (1994) Engineering and expression of a secreted murine TCR with reduced N-linked glycosylation. J Immunol 153:4111-21