Abstract

Several major aspects of senile dementia are being investigated in this project: The Alzheimer type (SDAT) accounts for about 50%, and the multi-infarct type (MID) for another 25% of the cases of this disorder, of which there are more than one million severe examples in this country. We are attempting to identify risk factors for these dementias in a prospective study involving 400 congnitively normal volunteers between the ages of 74 and 85. Cardiovascular risk factors for MID (including arrythmias, hypertension, etc.) are being intensively investigated. Special attention is given to serum lipids and lipoproteins, especially HDL and its subclasses as risk factors for stroke and dementia. Both possible exogenous and metabolic risk factors for Alzheimer's disease are being sought. The volunteers participate in the epidemiological, medical, neurological and psychological evaluations. Over a period of 6 years approximately one third of the subjects will develop dementing diseases affording an opportunity to follow the natural history of these disorders from their onset, and to study the development of intrusions and other neuropsychological phenomena. We will seek to identify criteria that might help in the differential diagnosis of dementia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS019234-04
Application #
3099744
Study Section
(SRC)
Project Start
1983-08-01
Project End
1990-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Weisen, S F; Frishman, W H; Aronson, M K et al. (1999) Self-rated health assessment and development of both cardiovascular and dementing illnesses in an ambulatory elderly population: a report from the Bronx Longitudinal Aging Study. Heart Dis 1:201-5
Zeitlin, A; Frishman, W H; Chang, C J (1997) The association of vitamin b 12 and folate blood levels with mortality and cardiovascular morbidity incidence in the old old: the Bronx aging study. Am J Ther 4:275-81
Crystal, H A; Dickson, D; Sliwinski, M et al. (1996) Associations of status and change measures of neuropsychological function with pathologic changes in elderly, originally nondemented subjects. Arch Neurol 53:82-7
Kahn, S; Frishman, W H; Weissman, S et al. (1996) Left ventricular hypertrophy on electrocardiogram: prognostic implications from a 10-year cohort study of older subjects: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc 44:524-9
Frishman, W H; Heiman, M; Karpenos, A et al. (1996) Twenty-four-hour ambulatory electrocardiography in elderly subjects: prevalence of various arrhythmias and prognostic implications (report from the Bronx Longitudinal Aging Study). Am Heart J 132:297-302
Feinfeld, D A; Guzik, H; Carvounis, C P et al. (1995) Sequential changes in renal function tests in the old old: results from the Bronx Longitudinal Aging Study. J Am Geriatr Soc 43:412-4
Schroeder, M M; Lipton, R B; Ritter, W et al. (1995) Event-related potential correlates of early processing in normal aging. Int J Neurosci 80:371-82
Hershman, D L; Simonoff, P A; Frishman, W H et al. (1995) Drug utilization in the old old and how it relates to self-perceived health and all-cause mortality: results from the Bronx Aging Study. J Am Geriatr Soc 43:356-60
Masur, D M; Sliwinski, M; Lipton, R B et al. (1994) Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology 44:1427-32
Dickson, D W; Davies, P; Bevona, C et al. (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> or = 80 years of age) humans. Acta Neuropathol 88:212-21

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