Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS019611-12
Application #
2263643
Study Section
Neurological Disorders Program Project Review B Committee (NSPB)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1988-12-01
Project End
1998-03-31
Budget Start
1995-04-01
Budget End
1998-03-31
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Organized Research Units
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Kisby, G E; Kabel, H; Hugon, J et al. (1999) Damage and repair of nerve cell DNA in toxic stress. Drug Metab Rev 31:589-618
Esclaire, F; Kisby, G; Spencer, P et al. (1999) The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. Exp Neurol 155:11-21
Tor-Agbidye, J; Palmer, V S; Lasarev, M R et al. (1999) Bioactivation of cyanide to cyanate in sulfur amino acid deficiency: relevance to neurological disease in humans subsisting on cassava. Toxicol Sci 50:228-35
Omelchenko, I A; Jain, R K; Junaid, M A et al. (1999) Neurotoxic potential of three structural analogs of beta-N-oxalyl-alpha,beta-diaminopropanoic acid (beta-ODAP). Neurochem Res 24:791-7
Spencer, P S (1999) Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 31:561-87
Tor-Agbidye, J; Palmer, V S; Sabri, M I et al. (1998) Dietary deficiency of cystine and methionine in rats alters thiol homeostasis required for cyanide detoxification. J Toxicol Environ Health A 55:583-95
Omelchenko, I A; Nelson, C S; Allen, C N (1997) Lead inhibition of N-methyl-D-aspartate receptors containing NR2A, NR2C and NR2D subunits. J Pharmacol Exp Ther 282:1458-64
Gold, B G (1997) Axonal regeneration of sensory nerves is delayed by continuous intrathecal infusion of nerve growth factor. Neuroscience 76:1153-8
Kisby, G E; Milne, J; Sweatt, C (1997) Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue. Neuroreport 8:1337-40
Wang, M S; Zeleny-Pooley, M; Gold, B G (1997) Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve. J Pharmacol Exp Ther 282:1084-93

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