This project is designed to investigate several novel aspects of the anatomical organization and pathology of the cerebral cortex which are directly relevant to cognitive functions. The issues addressed here follow directly on questions raised in other projects of this Program, especially on those pertaining to the neural basis of memory. The research is aimed at providing neuroanatomical characterizations of: (a) connectional links within specified cortical systems, and (b) the intrinsic structure of cortical regions participating in these systems. Such information is critical for the interpretation of experimental results based on any of the currently available approaches to the neurological basis of cognition in humans (e.g. the lesion method, PET, electrophysiology), and for the continued evaluation of theoretical formulations regarding the neural architecture and operations that may subserve cognition in primates. The proposal is divided into three subprojects: (1) high resolution tracing of connections from the parahippocampal cortex in monkeys, (2) topography of the human perforant pathway, and (3) modular organization of the human entorhinal cortex. Each subproject is based on a combination of modern histo- and immunocytochemical methods and conventional histology, to permit the dissection of chemically identified neurons and/or neurites. The information obtained from these tightly interrelated projects will contribute to a better understanding of the substrates of both normal and disordered human cognition at the cellular and connectional levels, and to a characterization of their alteration in conditions such as Alzheimer's disease.

Project Start
1999-07-01
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
17
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Mehta, Sonya; Inoue, Kayo; Rudrauf, David et al. (2016) Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity. Cortex 75:1-19
Immordino-Yang, Mary Helen; Yang, Xiao-Fei; Damasio, Hanna (2016) Cultural modes of expressing emotions influence how emotions are experienced. Emotion 16:1033-9
Scherer, Aaron M; Taber-Thomas, Bradley C; Tranel, Daniel (2015) A neuropsychological investigation of decisional certainty. Neuropsychologia 70:206-13
Ceschin, Rafael; Wisnowski, Jessica L; Paquette, Lisa B et al. (2015) Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants. Neuroimage Clin 8:462-72
Philippi, Carissa L; Tranel, Daniel; Duff, Melissa et al. (2015) Damage to the default mode network disrupts autobiographical memory retrieval. Soc Cogn Affect Neurosci 10:318-26
Guzmán-Vélez, Edmarie; Tranel, Daniel (2015) Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives. Neuropsychology 29:139-50
Derksen, B J; Duff, M C; Weldon, K et al. (2015) Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction. Memory 23:612-24
Kumaran, Dharshan; Warren, David E; Tranel, Daniel (2015) Damage to the Ventromedial Prefrontal Cortex Impairs Learning from Observed Outcomes. Cereb Cortex 25:4504-18
Ceschin, Rafael; Lee, Vince K; Schmithorst, Vince et al. (2015) Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy. Neuroimage Clin 9:322-37
Hannula, Deborah E; Tranel, Daniel; Allen, John S et al. (2015) Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia. Neuropsychology 29:126-38

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