Little is known regarding the effects of damage to specific regions of the human brain when this damage occurs early in life, although there is reason to believe that certain impairments of cognition and behavior are a consequence of early-onset brain damage. The NINDS has identified as high research priorities the gathering of more precise descriptions of behavior patterns and developmental disorders, and the achievement of greater understanding of the neural basis of cognition, emotion, and their interaction. Lesion method studies of individuals who have sustained early-onset focal brain damage are an important means to fulfill such priorities, and during the current funding period we have conducted pilot studies of adults with early-onset focal brain damage and marked cognitive and behavioral impairments. Conditions causing focal brain damage in childhood are not common, but a sufficient number of patients is now available for systematic studies. Here we propose to establish a registry of patients with damage to circumscribed brain regions acquired during development, namely during the perinatal period, infancy, childhood, or adolescence, and to perform hypothesis-driven studies of these individuals using: (1) precise description of brain lesions using MRI with 3-D reconstruction, (2) comprehensive characterization of cognition and behavior with standardized, age-appropriate neuropsychological measures, (3) standardized indices of functional outcome (academic achievement, employment, quality of life, and family burden), and (4) experimental measures of cognition and behavior, with a focus on emotion, moral reasoning and social competence Delineation of relationships between damage to specific neural systems early in life and the short- and long-term consequences for cognition and behavior should provide fundamental information which will be relevant to the understanding of human development, and permit better evaluation and treatment of treatment of neurobehavioral disorders with onset in childhood.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
3P01NS019632-19S1
Application #
6565190
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2001-07-15
Project End
2002-06-30
Budget Start
Budget End
Support Year
19
Fiscal Year
2002
Total Cost
$110,268
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Mehta, Sonya; Inoue, Kayo; Rudrauf, David et al. (2016) Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity. Cortex 75:1-19
Immordino-Yang, Mary Helen; Yang, Xiao-Fei; Damasio, Hanna (2016) Cultural modes of expressing emotions influence how emotions are experienced. Emotion 16:1033-9
Scherer, Aaron M; Taber-Thomas, Bradley C; Tranel, Daniel (2015) A neuropsychological investigation of decisional certainty. Neuropsychologia 70:206-13
Ceschin, Rafael; Wisnowski, Jessica L; Paquette, Lisa B et al. (2015) Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants. Neuroimage Clin 8:462-72
Philippi, Carissa L; Tranel, Daniel; Duff, Melissa et al. (2015) Damage to the default mode network disrupts autobiographical memory retrieval. Soc Cogn Affect Neurosci 10:318-26
Guzmán-Vélez, Edmarie; Tranel, Daniel (2015) Does bilingualism contribute to cognitive reserve? Cognitive and neural perspectives. Neuropsychology 29:139-50
Derksen, B J; Duff, M C; Weldon, K et al. (2015) Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction. Memory 23:612-24
Kumaran, Dharshan; Warren, David E; Tranel, Daniel (2015) Damage to the Ventromedial Prefrontal Cortex Impairs Learning from Observed Outcomes. Cereb Cortex 25:4504-18
Ceschin, Rafael; Lee, Vince K; Schmithorst, Vince et al. (2015) Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy. Neuroimage Clin 9:322-37
Hannula, Deborah E; Tranel, Daniel; Allen, John S et al. (2015) Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia. Neuropsychology 29:126-38

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