We seek support to continue multidisciplinary studies of the development of the cerebral cortex. With the help of the initial Senator Javits Center we have established a team of investigators with expertise in molecular biology, immunocytochemistry, laser microscopy, electron microscopy, receptor pharmacology, computer imaging, and electrophysiology to join forces to explore five major themes: (1) Molecular mechanisms of neuronal migration to the neocortex; (2) Regulation of cell phenotype in developing neocortex; (3) Development of cortical circuitry in primate neocortex; (4) Ontogeny of major neurotransmitter receptors in the primate cerebral cortex; and (5) Development and modulation of synaptic plasticity studies performed during the previous cycle of the grant and represent some of the most advanced neurobiological approaches that can be applied to the complex development problems involved in cortical ontogeny. Cerebral cortex is the site of many mental and neurological dysfunctions whose cause can be traced to genetic and acquired developmental abnormalities. Prevention and healing of these disorders requires understanding molecular and cellular mechanisms involved in normal cortical development. Our experience is that a program project of this scope promotes communication between investigators with different backgrounds, fosters research collaboration, and enables comprehensive, multifaceted analyses that are either not possible or practical for individual investigators supported by separate research grants.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS022807-09
Application #
3099977
Study Section
Special Emphasis Panel (SRC (03))
Project Start
1985-09-01
Project End
1995-03-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Wang, F; Lidow, M S (1997) Alpha 2A-adrenergic receptors are expressed by diverse cell types in the fetal primate cerebral wall. J Comp Neurol 378:493-507
Redmond, L; Xie, H; Ziskind-Conhaim, L et al. (1997) Cues intrinsic to the spinal cord determine the pattern and timing of primary afferent growth. Dev Biol 182:205-18
Anton, E S; Cameron, R S; Rakic, P (1996) Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. J Neurosci 16:2283-93
Fryer, H J; Hockfield, S (1996) The role of polysialic acid and other carbohydrate polymers in neural structural plasticity. Curr Opin Neurobiol 6:113-8

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