Abstract

The purpose of this core is to provide centralized care, breeding, genotyping and quality control of transgenic and knockout animals for use by investigators in the program project. The core will also provide a mechanism for the distribution of new experimental transgenic and knockout models to the Jackson Laboratory Induced Mutant Resource, and to program and non-program project investigators both at the University of Iowa and outside the institution. The main responsibilities of the Core will be: 1) maintenance of genetic stocks; 2) genotyping transgenic and knockout animals; 3) provision of experimental and control mice to investigators; and 4) quality control.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS024621-15
Application #
6452795
Study Section
Project Start
2001-03-01
Project End
2002-05-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
15
Fiscal Year
2001
Total Cost
$111,112
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Ketsawatsomkron, Pimonrat; Keen, Henry L; Davis, Deborah R et al. (2016) Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-? Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension 67:214-22
Dayal, Sanjana; Gu, Sean X; Hutchins, Ryan D et al. (2015) Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arterioscler Thromb Vasc Biol 35:1798-804
Rodionov, Roman N; Jarzebska, Natalia; Weiss, Norbert et al. (2014) AGXT2: a promiscuous aminotransferase. Trends Pharmacol Sci 35:575-82
De Silva, T Michael; Modrick, Mary L; Ketsawatsomkron, Pimonrat et al. (2014) Role of peroxisome proliferator-activated receptor-? in vascular muscle in the cerebral circulation. Hypertension 64:1088-93
Chrissobolis, Sophocles; Drummond, Grant R; Faraci, Frank M et al. (2014) Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens 32:1815-21
Pelham, Christopher J; Keen, Henry L; Lentz, Steven R et al. (2013) Dominant negative PPAR? promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. Am J Physiol Regul Integr Comp Physiol 304:R690-701
Lynch, Cynthia M; Kinzenbaw, Dale A; Chen, Xunxheng et al. (2013) Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke 44:3195-201
Sigmund, Curt D (2013) A clinical link between peroxisome proliferator-activated receptor ? and the renin-angiotensin system. Arterioscler Thromb Vasc Biol 33:676-8
Hilzendeger, Aline M; Cassell, Martin D; Davis, Deborah R et al. (2013) Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension 61:716-22
Khoo, Nicholas K H; Hebbar, Sachin; Zhao, Weiling et al. (2013) Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy. Redox Biol 1:70-9

Showing the most recent 10 out of 432 publications