This project describes the application of quantitative neuroimaging and neurophysiological techniques to the study of the AIDS dementia complex (ADC). FDG/PET, spin-echo MRI and quantitative EEG/event-related potentials (ERP's) will be employed to investigate the pathophysiology of the neuropsychiatric symptoms of ADC and the nature and evolution of subcortical dementia. Using FDG/PET, we plan to confirm and extend our previous finding of relative subcortical hypermetabolism early in the course of ADC, and to define metabolic covariance patterns that provide sensitive, quantitative indices of disease severity and progression. Since quantitative MRI measures of CSF volume may be more sensitive to the presence of HIV infection than subjective atrophy ratings, and having developed and validated a quantitative MRI method for analyzing serial MRI scans obtained from normal volunteer subjects, we propose to use well-characterized MRI techniques to evaluate -- in cross-sectional and longitudinal studies of asymptomatic and mildly symptomatic seropositives -- the diagnostic and prognostic value of serial measurements of CSF, gray-matter and white-matter compartmental volumes. Finally, standard electrophysiologic measures (EEG power and ERP latency) obtained during FDG/PET imaging will be correlated with clinical, neurobehavioral and metabolic indices of disease severity in an effort to assess the potential of surface EEG recording for ADC diagnosis and staging.

Project Start
1997-02-01
Project End
1999-01-31
Budget Start
Budget End
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Price, R W; Yiannoutsos, C T; Clifford, D B et al. (1999) Neurological outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team. AIDS 13:1677-85
Rehm, K; Lakshminaryan, K; Frutiger, S et al. (1998) A symbolic environment for visualizing activated foci in functional neuroimaging datasets. Med Image Anal 2:215-26
Liow, J S; Strother, S C; Rehm, K et al. (1997) Improved resolution for PET volume imaging through three-dimensional iterative reconstruction. J Nucl Med 38:1623-31
Sidtis, J J; Dafni, U; Slasor, P et al. (1997) Stable neurological function in subjects treated with 2'3'-dideoxyinosine. J Neurovirol 3:233-40
Price, R W (1996) AIDS dementia complex: a complex, slow virus ""model"" of acquired genetic neurodegenerative disease. Cold Spring Harb Symp Quant Biol 61:759-70
Rottenberg, D A; Sidtis, J J; Strother, S C et al. (1996) Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 37:1133-41
Wang, G J; Thayer, S A (1996) Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons. J Neurophysiol 76:1611-21
Price, R W (1996) The cellular basis of central nervous system HIV-1 infection and the AIDS dementia complex: introduction. J NeuroAIDS 1:1-29
Price, R W (1996) Neurological complications of HIV infection. Lancet 348:445-52
Price, R W (1995) Management of AIDS dementia complex and HIV-1 infection of the nervous system. AIDS 9 Suppl A:S221-36

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