The Core houses a repository of brain specimens from patients who died with HIV-1 infection and AIDS. This consists largely of pediatric cases, with a small number of adult cases aswell. There is currently paraffin-embedded tissue from 79 cases, with specimens snap frozen in isopentane cooled with liquid nitrogen and stored at -80 degrees C from 24 of these cases, with many collected within 12 hours of death. Because of the success of treatment of pediatric AIDS with highly active antiretroviral therapy (HAART), the number of deaths due to HIV-1 has fallen, with a consequent diminution in the number of cases added to the Brain Bank over the last few years. Any cases that do come to post mortem examination, with proper consent for autopsy, will be added to the Brain Bank, with an expected maximum of three cases per year (see letter from consultant, Dr. George McSherry, of the Division of Pediatric Allergy, Immunology and Infectious Diseases, and of the pediatric AIDS center at University Hospital, Newark). Inthe autopsy protocol, the brain is divided in half, with samples taken from over 20 regions for snap freezing from one half, while over 50 regions are sampled for paraffin embedding from the other half.
| Schutt, Charles R; Gendelman, Howard E; Mosley, R Lee (2018) Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson's disease. Mol Neurodegener 13:26 |
| Sillman, Brady; Bade, Aditya N; Dash, Prasanta K et al. (2018) Creation of a long-acting nanoformulated dolutegravir. Nat Commun 9:443 |
| Thomas, Midhun B; Gnanadhas, Divya Prakash; Dash, Prasanta K et al. (2018) Modulating cellular autophagy for controlled antiretroviral drug release. Nanomedicine (Lond) 13:2139-2154 |
| McMillan, JoEllyn; Szlachetka, Adam; Slack, Lara et al. (2018) Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques. Antimicrob Agents Chemother 62: |
| Sillman, Brady; Woldstad, Christopher; Mcmillan, Joellyn et al. (2018) Neuropathogenesis of human immunodeficiency virus infection. Handb Clin Neurol 152:21-40 |
| Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65 |
| Kevadiya, Bhavesh D; Ottemann, Brendan M; Thomas, Midhun Ben et al. (2018) Neurotheranostics as personalized medicines. Adv Drug Deliv Rev : |
| McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS : |
| Araínga, Mariluz; Edagwa, Benson; Mosley, R Lee et al. (2017) A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology 14:17 |
| Gnanadhas, Divya Prakash; Dash, Prasanta K; Sillman, Brady et al. (2017) Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs. J Clin Invest 127:857-873 |
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