Core - Animal Surgery

Penney, John B.

Abstract

This core will provide lesioned animals and animal care for all the projects based at Massachusetts General Hospital. It will provide training in the same lesioning techniques for the project based at the University of Massachusetts, project 4. It will also provide evaluation of the quality of the lesions for all the projects. By having a single core create and evaluate the lesions, the results produced by the different projects can be directly compared to one another helping each project in the interpretation of its own results, increasing the interactions between the projects, and making the results more generalizable. Having a single group perform the lesions will increase the accuracy and reproducibility of the lesions because of the expertise that the surgeons will obtain due to extra practice.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Program Projects (P01)
• Project #: 5P01NS031579-03
• Application #: 5215431
• Support Year: 3
• Fiscal Year: 1996

Publications

Andreassen, Ole A; Dedeoglu, Alpaslan; Stanojevic, Violeta et al. (2002) Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis 11:410-24

Swerdlow, N R; Young, A B (2001) Neuropathology in Tourette syndrome: an update. Adv Neurol 85:151-61

Andreassen, O A; Ferrante, R J; Klivenyi, P et al. (2001) Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Exp Neurol 168:356-63

Orlando, L R; Alsdorf, S A; Penney Jr, J B et al. (2001) The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity. Exp Neurol 167:196-204

Augood, S J; Hollingsworth, Z R; Standaert, D G et al. (2000) Localization of dopaminergic markers in the human subthalamic nucleus. J Comp Neurol 421:247-55

Klivenyi, P; Andreassen, O A; Ferrante, R J et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J Neurosci 20:7-Jan

Dunah, A W; Wang, Y; Yasuda, R P et al. (2000) Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease. Mol Pharmacol 57:342-52

Jenkins, B G; Klivenyi, P; Kustermann, E et al. (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J Neurochem 74:2108-19

Kuppenbender, K D; Standaert, D G; Feuerstein, T J et al. (2000) Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J Comp Neurol 419:407-21

Ferrante, R J; Hantraye, P; Brouillet, E et al. (1999) Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase. Brain Res 823:177-82