Abstract

The recent cloning of multiple receptor subtypes for neurotransmitters, such as glutamate, GABA, dopamine, and acetylcholine has made possible the opportunity to develop probes to examine the neuronal localization and distribution of receptor mRNA and protein for these receptors in the basal ganglia. The overall goal of this core will be to develop well- characterized antibodies and oligonucleotide probes for use by the investigators in this program project. This core will serve the needs of investigators in projects 1, 2, 3 and 4. The development of these probes, together with the ones already in hand, is essential to achieving the goals of individual projects and in providing uniformity across projects so that more meaningful comparisons between studies can be made.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS031579-04
Application #
6243761
Study Section
Project Start
1997-01-01
Project End
1997-12-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Andreassen, Ole A; Dedeoglu, Alpaslan; Stanojevic, Violeta et al. (2002) Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis 11:410-24
Andreassen, O A; Ferrante, R J; Klivenyi, P et al. (2001) Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid. Exp Neurol 168:356-63
Orlando, L R; Alsdorf, S A; Penney Jr, J B et al. (2001) The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity. Exp Neurol 167:196-204
Swerdlow, N R; Young, A B (2001) Neuropathology in Tourette syndrome: an update. Adv Neurol 85:151-61
Augood, S J; Hollingsworth, Z R; Standaert, D G et al. (2000) Localization of dopaminergic markers in the human subthalamic nucleus. J Comp Neurol 421:247-55
Klivenyi, P; Andreassen, O A; Ferrante, R J et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J Neurosci 20:7-Jan
Dunah, A W; Wang, Y; Yasuda, R P et al. (2000) Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease. Mol Pharmacol 57:342-52
Jenkins, B G; Klivenyi, P; Kustermann, E et al. (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice. J Neurochem 74:2108-19
Kuppenbender, K D; Standaert, D G; Feuerstein, T J et al. (2000) Expression of NMDA receptor subunit mRNAs in neurochemically identified projection and interneurons in the human striatum. J Comp Neurol 419:407-21
Standaert, D G; Friberg, I K; Landwehrmeyer, G B et al. (1999) Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. Brain Res Mol Brain Res 64:11-23

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