Abstract

This neuropsychological core will provide centralized, cost-effective data collection. It will coordinate reliable neuropsychological test administration, scoring, and data collation. The goal of Core D is to further define observed attention and memory deficits in Lyme disease and to more fully characterize neurobehavioral function in adult and pediatric patients with early and late stages of infection.
The specific aims of the Core are: 1. To coordinate neuropsychological data collection in a cost-effective manner 2. To provide a centralized and standardized means of assessment which is consistent across Projects and subject groups. 3. To provide initial data reduction in preparation for project specific statistical analyses 4. To train and supervise study psychometricians 5. To ensure quality assurance with respect to all neuropsychological assessment procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS034092-05
Application #
6443424
Study Section
Project Start
2001-04-01
Project End
2003-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2001
Total Cost
$242,910
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Gilhar, A; Ullmann, Y; Karry, R et al. (2004) Ageing of human epidermis: the role of apoptosis, Fas and telomerase. Br J Dermatol 150:56-63
Fikrig, Erol; Coyle, Patricia K; Schutzer, Steven E et al. (2004) Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease. J Clin Microbiol 42:1243-6
Kalish, Richard S; Wood, Jonathan A; Golde, William et al. (2003) Human T lymphocyte response to Borrelia burgdorferi infection: no correlation between human leukocyte function antigen type 1 peptide response and clinical status. J Infect Dis 187:102-8
Gilhar, Amos; Landau, Marina; Assy, Bedia et al. (2002) Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 138:916-22
Kumaran, D; Eswaramoorthy, S; Luft, B J et al. (2001) Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi. EMBO J 20:971-8
Schutzer, S E; Coyle, P K; Chen, D (2001) The role of the allergist in Lyme disease. Allergy Asthma Proc 22:29-31
Gilhar, A; Landau, M; Assy, B et al. (2001) Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. J Invest Dermatol 117:1357-62
Kalish, R S (2000) Pemphigus vulgaris: the other half of the story. J Clin Invest 106:1433-5
Belman, A L (1999) Tick-borne diseases. Semin Pediatr Neurol 6:249-66
Schutzer, S E; Coyle, P K; Reid, P et al. (1999) Borrelia burgdorferi-specific immune complexes in acute Lyme disease. JAMA 282:1942-6

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