Abstract

The purpose of the Animal Core is primarily to assist investigators in animal surgery, electrophysiology, behavioral testing, and imaging. This Core facility consists of personnel and equipment needed to perform procedures described in Projects 1-4. The Animal Core will conduct general animal preparation, including anesthesia, tracheotomy, catheterizations, temperature monitoring and regulation of physiological variables. The Core will assist investigators in preparing the animal models of spinal cord injury described in the individual projects. In addition, expertise is available to modify experimental animal preparations that may be required for future investigations. Personnel will also assist in the behavioral testing of the animal preparations that may be required for future investigations. Personnel will also assist in the behavioral testing of the rats following spinal cord injury, as well as in electrophysiological assessment of specific white matter tracts. Finally, this Core will provide expertise in MRI for the visualization of spinal cord contusions within the human spinal cord project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS038665-02
Application #
6478905
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2001-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
$53,568
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Williams, Ryan R; Henao, Martha; Pearse, Damien D et al. (2015) Permissive Schwann cell graft/spinal cord interfaces for axon regeneration. Cell Transplant 24:115-31
Flora, Govinder; Joseph, Gravil; Patel, Samik et al. (2013) Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury. Cell Transplant 22:2203-17
Williams, Ryan R; Pearse, Damien D; Tresco, Patrick A et al. (2012) The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration. J Gene Med 14:20-34
Hill, Caitlin E; Brodak, Danika M; Bartlett Bunge, Mary (2012) Dissociated predegenerated peripheral nerve transplants for spinal cord injury repair: a comprehensive assessment of their effects on regeneration and functional recovery compared to Schwann cell transplants. J Neurotrauma 29:2226-43
Maggio, Dominic M; Chatzipanteli, Katina; Masters, Neil et al. (2012) Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury. J Neurotrauma 29:2244-9
Hill, Caitlin E; Guller, Yelena; Raffa, Scott J et al. (2010) A calpain inhibitor enhances the survival of Schwann cells in vitro and after transplantation into the injured spinal cord. J Neurotrauma 27:1685-95
Fortun, Jenny; Hill, Caitlin E; Bunge, Mary Bartlett (2009) Combinatorial strategies with Schwann cell transplantation to improve repair of the injured spinal cord. Neurosci Lett 456:124-32
Talbott, Jason F; Cao, Qilin; Bertram, James et al. (2007) CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp Neurol 204:485-9
Golden, Kevin L; Pearse, Damien D; Blits, Bas et al. (2007) Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp Neurol 207:203-17
Davis, Angela R; Lotocki, George; Marcillo, Alex E et al. (2007) FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. J Neurotrauma 24:823-34

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