Abstract

The Behavioral Core is core-directed by Alan R. Light and Charles Vierck. The behavioral facility is responsible for all behavioral testing proposed in Projects 1 and 3. In these projects, it is important to assess changes in the sensitiveness of rats and mice to thermal and mechanical stimulation of cutaneous surfaces before and after administration of inflammatory mediators or other treatments of peripheral tissue or nerves. The behavioral core utilizes testing strategies originated by Dr. Vierck and Light have collaborated in this manner for some time, communicating frequently about the development of the proposed techniques and the analysis of results obtained with different manipulations. Furthermore, Dr. Vierck will travel from Gainesville to Chapel Hill once a month in order to review progress in the behavioral paradigms and to meet with personnel using these paradigms.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS039420-01A1
Application #
6340080
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2000-07-25
Project End
2005-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$185,989
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Garraway, Sandra M; Mendell, Lorne M (2007) Spinal cord transection enhances afferent-evoked inhibition in lamina II neurons and abolishes BDNF-induced facilitation of their sensory input. J Neurotrauma 24:379-90
Zhu, Weiguo; Oxford, Gerry S (2007) Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci 34:689-700
Lin, Ting; Li, Kai; Zhang, Fei-Yu et al. (2007) Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models. J Neuroimmunol 192:40-8
Zhu, Weiguo; Xu, Pin; Cuascut, Fernando X et al. (2007) Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. J Neurosci 27:13770-80
Light, Alan R; Wu, Ying; Hughen, Ronald W et al. (2006) Purinergic receptors activating rapid intracellular Ca increases in microglia. Neuron Glia Biol 2:125-138
Garraway, Sandra M; Anderson, Aileen J; Mendell, Lorne M (2005) BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury. J Neurophysiol 94:1798-804
Arvanian, Victor L; Motin, Vladimir; Mendell, Lorne M (2005) Comparison of metabotropic glutamate receptor responses at segmental and descending inputs to motoneurons in neonatal rat spinal cord. J Pharmacol Exp Ther 312:669-77
Wu, Ying; Willcockson, Helen H; Maixner, William et al. (2004) Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. J Pain 5:48-55
Liu, L; Zhu, W; Zhang, Z-S et al. (2004) Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. J Neurophysiol 91:1482-91
Horton, April C; Ehlers, Michael D (2004) Secretory trafficking in neuronal dendrites. Nat Cell Biol 6:585-91

Showing the most recent 10 out of 23 publications