Abstract

Thorough analyses of molecular mechanisms in cellular and developmental neuroscience requires an array of imaging tools and expertise. The purpose of this program project core is to provide the instrumentation and technical support to enable research staff in the three program laboratories to perform a wide range of imaging applications and image processing to extract quantitative mophometric data. The applications range from three types of confocal microscopy to wide-field fluorescence time-lapse microscopy to standard format imaging of fixed tissues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS040043-09
Application #
7615618
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
9
Fiscal Year
2008
Total Cost
$169,782
Indirect Cost

  Institution

Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Liu, Judy S; Schubert, Christian R; Fu, Xiaoqin et al. (2012) Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell 47:707-21
Tcherkezian, Joseph; Brittis, Perry A; Thomas, Franziska et al. (2010) Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell 141:632-44
Kim, Seonhee; Lehtinen, Maria K; Sessa, Alessandro et al. (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66:69-84
Loya, Carlos M; Van Vactor, David; Fulga, Tudor A (2010) Understanding neuronal connectivity through the post-transcriptional toolkit. Genes Dev 24:625-35
Loya, Carlos M; Lu, Cecilia S; Van Vactor, David et al. (2009) Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods 6:897-903
Neal, Jason; Takahashi, Masaya; Silva, Matthew et al. (2007) Insights into the gyrification of developing ferret brain by magnetic resonance imaging. J Anat 210:66-77
Lu, Jie; Lian, Gewei; Lenkinski, Robert et al. (2007) Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet 16:1661-75
Sheen, Volney L; Ferland, Russell J; Neal, Jason et al. (2006) Neocortical neuronal arrangement in Miller Dieker syndrome. Acta Neuropathol 111:489-96
Deuel, Thomas A S; Liu, Judy S; Corbo, Joseph C et al. (2006) Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron 49:41-53
Feng, Yuanyi; Chen, Ming Hui; Moskowitz, Ivan P et al. (2006) Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A 103:19836-41

Showing the most recent 10 out of 35 publications