Abstract

Progress in understanding and treating Parkinson's disease depends upon adequate animal models. The centralized production and maintenance of animals for the various projects will allow direct correlation and comparison of the results on morphological, biochemical, pharmacological, and molecular manipulations described in this program project application. The primary function of the Animal Core is to generate animals with striatal DA depletions, including rats with 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal system and mice treated with the neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), for use in the Projects. In addition, the Core will provide 6-OHDA-lesioned rats injected with retrograde tracers. The Core does the surgeries and drug treatments and is extensively involved in the overseeing the quality of the treatments. The animals produced and maintained by the Core will be accessed extensively by all four Projects, and provide the cornerstone of the studies that are proposed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS044282-01
Application #
6614269
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
1
Fiscal Year
2002
Total Cost
$162,335
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Mattison, Hayley A; Nie, Hui; Gao, Huiming et al. (2013) Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice. J Neuroimmunol 257:110-5
Wei, Peng; Pattarini, Roberto; Rong, Yongqi et al. (2012) The Cbln family of proteins interact with multiple signaling pathways. J Neurochem 121:717-29
Rong, Yongqi; Wei, Peng; Parris, Jennifer et al. (2012) Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J Neurochem 120:528-40
Garcia, Bonnie G; Neely, M Diana; Deutch, Ariel Y (2010) Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cereb Cortex 20:2423-32
Nikandrova, Yelyzaveta A; Jiao, Yuxia; Baucum, Anthony J et al. (2010) Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity. J Biol Chem 285:923-34
Baucum 2nd, Anthony J; Jalan-Sakrikar, Nidhi; Jiao, Yuxia et al. (2010) Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach. Mol Cell Proteomics 9:1243-59
Kusnoor, S V; Parris, J; Muly, E C et al. (2010) Extracerebellar role for Cerebellin1: modulation of dendritic spine density and synapses in striatal medium spiny neurons. J Comp Neurol 518:2525-37
Kusnoor, Sheila V; Muly, E Chris; Morgan, James I et al. (2009) Is the loss of thalamostriatal neurons protective in parkinsonism? Parkinsonism Relat Disord 15 Suppl 3:S162-6
Nayyar, Tultul; Bubser, Michael; Ferguson, Marcus C et al. (2009) Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Eur J Neurosci 30:207-16
Neely, M Diana; Robert, Elizabeth M; Baucum, Anthony J et al. (2009) Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res 1274:55-65

Showing the most recent 10 out of 31 publications