The overall goal of Project 5 will be characterize the functional role of subcortical loops through the basal ganglia and through the cerebellum in the integration of motor programs across time. We will use a dual-chamber recording technique to study pairs of neurons, one in a targeted area of the frontal cortex and the other in the globus pallidus or in the cerebellar nucleus. A cortical and a subcortical neuron pair will be selected based on the likelihood that the subcortical neuron sends synaptic input, via thalamus, to the cortical neuron. In this manner, single units at the pair of sites can be studied simultaneously, while a monkey performs a task that integrates motor programs across time. The three tasks that we will study are designed are designed to parallel the tasks being studied in other projects of this PPG, so that we can profit optimally from the close interactions promoted by this comprehensive program of motor systems research. To interface with Project 2, we will study the on-line correction of errors that result from small perturbations introduced while the task is being performed. To interface with Project 3, we will study the execution of skilled movement sequences that have been learned through extended periods of practice. To interface with Project 4, we will study the sequential movements made when copying geometrical figures. We will use both paired-site single unit recordings and microinjection of antagonists to inactivate the subcortical site. In this manner, we will investigate how output signals from single neurons located in identified channels passing through the basal ganglia and through the cerebellum function to regulate the signals that are simultaneously recorded from a cortical neuron.
| Kahn, Ari E; Mattar, Marcelo G; Vettel, Jean M et al. (2017) Structural Pathways Supporting Swift Acquisition of New Visuomotor Skills. Cereb Cortex 27:173-184 |
| Ramkumar, Pavan; Acuna, Daniel E; Berniker, Max et al. (2016) Chunking as the result of an efficiency computation trade-off. Nat Commun 7:12176 |
| Ohbayashi, Machiko; Picard, Nathalie; Strick, Peter L (2016) Inactivation of the Dorsal Premotor Area Disrupts Internally Generated, But Not Visually Guided, Sequential Movements. J Neurosci 36:1971-6 |
| Crossley, Matthew J; Horvitz, Jon C; Balsam, Peter D et al. (2016) Expanding the role of striatal cholinergic interneurons and the midbrain dopamine system in appetitive instrumental conditioning. J Neurophysiol 115:240-54 |
| Soto, Fabian A; Vucovich, Lauren; Musgrave, Robert et al. (2015) General recognition theory with individual differences: a new method for examining perceptual and decisional interactions with an application to face perception. Psychon Bull Rev 22:88-111 |
| Graybiel, Ann M; Grafton, Scott T (2015) The striatum: where skills and habits meet. Cold Spring Harb Perspect Biol 7:a021691 |
| Helie, Sebastien; Roeder, Jessica L; Vucovich, Lauren et al. (2015) A neurocomputational model of automatic sequence production. J Cogn Neurosci 27:1412-26 |
| Bassett, Danielle S; Yang, Muzhi; Wymbs, Nicholas F et al. (2015) Learning-induced autonomy of sensorimotor systems. Nat Neurosci 18:744-51 |
| Smith, J David; Zakrzewski, Alexandria C; Herberger, Eric R et al. (2015) The time course of explicit and implicit categorization. Atten Percept Psychophys 77:2476-90 |
| Glaser, Joshua I; Zamft, Bradley M; Church, George M et al. (2015) Puzzle Imaging: Using Large-Scale Dimensionality Reduction Algorithms for Localization. PLoS One 10:e0131593 |
Showing the most recent 10 out of 114 publications
