Abstract

Core C is a facility designed to provide state-of-the-art mouse and rat husbandry, veterinary care, mouse colony management and a genotyping service.
Its aims are: 1) to maintain breeding colonies of knockout mouse lines, including estrogen receptor subtype a .(ERKO) and P (pERKO) knockouts, P450 estrogen aromatase knockouts (ARKO), and cocaine and amphetamine regulated transcript (CART) knockouts of both sexes;2) to screen via standard genotyping for selection of breeders, for colony expansion, and for supply of animals to projects within the program;and 3) to provide additional husbandry and special care needs for rodent models purchased from vendors or provided by collaborators, including tfm rats and reproductively senescent male (RSM) and female (RSF) rodents (Wistar rats, C57BL/6 mice). This core facility will be a shared resource of the program and will play a central role in our investigations of sex steroids and neuroprotection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS049210-05
Application #
7774313
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2009-03-01
Budget End
2010-02-28
Support Year
5
Fiscal Year
2009
Total Cost
$205,844
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Jia, Jia; Davis, Catherine M; Zhang, Wenri et al. (2016) Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium. Exp Neurol 279:75-85
Zhang, Wenri; Cheng, Jian; Vagnerova, Kamila et al. (2014) Effects of androgens on early post-ischemic neurogenesis in mice. Transl Stroke Res 5:301-11
Ren, Xuefang; Akiyoshi, Kozaburo; Grafe, Marjorie R et al. (2012) Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity. Metab Brain Dis 27:7-15
Li, Jun; Siegel, Matt; Yuan, Mike et al. (2011) Estrogen enhances neurogenesis and behavioral recovery after stroke. J Cereb Blood Flow Metab 31:413-25
Cheng, Jian; Uchida, Masayoshi; Zhang, Wenri et al. (2011) Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia. J Cereb Blood Flow Metab 31:339-50
Woodworth, K Nina; Palmateer, Julie; Swide, Joseph et al. (2011) Short- and long-term behavioral effects of exposure to 21%, 40% and 100% oxygen after perinatal hypoxia-ischemia in the rat. Int J Dev Neurosci 29:629-38
Ren, Xuefang; Akiyoshi, Kozaburo; Vandenbark, Arthur A et al. (2011) Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke. Stroke 42:2578-83
Ren, Xuefang; Akiyoshi, Kozaburo; Dziennis, Suzan et al. (2011) Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci 31:8556-63
Bodhankar, Sheetal; Wang, Chunhe; Vandenbark, Arthur A et al. (2011) Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur J Immunol 41:1165-75
Lee, Craig R; Imig, John D; Edin, Matthew L et al. (2010) Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J 24:3770-81

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