Abstract

The scientific core consists of a large optical imaging laboratory to support program project members with state of the art equipment and methodologies.
Aim 1 To support investigators in imaging cerebral blood flow using laser speckle contrast imaging.
Aim 2 to support investigators in imaging total hemoglobin concentration and oxygenation using multi-spectral optical imaging.
Aim 3 To support investigators in imaging the cerebral metabolic rate of oxygen.
Aim 4 To support investigators in imaging neuronal membrane potential using voltage-sensitive dye imaging.
Aim 5 To support investigators with two-photon and optical coherence microscopy of intracortical micro-vessels. Taken together, these aims both support the scientific aims of the program project as a whole, while the needs of the projects serve to advance the methodology to facilitate investigator driven analyses

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS055104-05
Application #
8292131
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$280,621
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Kura, Sreekanth; Xie, Hongyu; Fu, Buyin et al. (2018) Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex. J Neural Eng 15:035003
Sadeghian, Homa; Lacoste, Baptiste; Qin, Tao et al. (2018) Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis. Ann Neurol 84:409-423
Chung, David Y; Sadeghian, Homa; Qin, Tao et al. (2018) Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex :
Takase, Hajime; Liang, Anna C; Miyamoto, Nobukazu et al. (2018) Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress. Neurosci Lett 668:120-125
Maki, Takakuni; Choi, Yoon Kyung; Miyamoto, Nobukazu et al. (2018) A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells 36:751-760
Tang, Jianbo; Erdener, Sefik Evren; Li, Baoqiang et al. (2018) Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography. J Biophotonics 11:
Chung, David Y; Sugimoto, Kazutaka; Fischer, Paul et al. (2018) Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods 309:143-146
Gómez, Carlos A; Sutin, Jason; Wu, Weicheng et al. (2018) Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex. PLoS One 13:e0194578
Maki, Takakuni; Morancho, Anna; Martinez-San Segundo, Pablo et al. (2018) Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke 49:1003-1010
Wang, Hui; Magnain, Caroline; Wang, Ruopeng et al. (2018) as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity. Neuroimage 165:56-68

Showing the most recent 10 out of 240 publications