Abstract

Osteoarthritis is a prevalent and costly disease, second only to cardiovascular disease in producing severe chronic disability. Because it is extremely difficult to study osteoarthritis in its early stages in human beings, study of an appropriate animal model of naturally occurring disease is necessary to understand its pathogenesis. This laboratory has recently identified a high level of naturally occurring osteoarthritis, with morphologic features very similar to those seen in human beings, in the knee joints of captive female cynomolgus monkeys (Macaca fascicularis). The objectives of this project are to further characterize osteoarthritis in these animals; to develop and implement a quantitative grading scheme to assess lesion severity; and, using this scheme, to determine the effects of estrogen deficiency and androgenic hormone treatment on the disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Program Projects (P01)
Project #
5P01RR008562-02
Application #
3767363
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106

  Publications

Di Cesare, P E; Fang, C; Leslie, M P et al. (1999) Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage. J Orthop Res 17:437-45
Anderson, J J; Anthony, M S; Cline, J M et al. (1999) Health potential of soy isoflavones for menopausal women. Public Health Nutr 2:489-504
Ekman, S; Carlson, C S (1998) The pathophysiology of osteochondrosis. Vet Clin North Am Small Anim Pract 28:17-32
Tansey, G; Hughes Jr, C L; Cline, J M et al. (1998) Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc Soc Exp Biol Med 217:340-4
Di Cesare, P E; Carlson, C S; Attur, M et al. (1998) Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma. J Orthop Res 16:667-74
Obasanjo, I O; Cline, J M; Schmotzer, S et al. (1998) Nandrolone decanoate causes pathologic changes in the uterus of surgically postmenopausal female cynomolgus macaques. Menopause 5:163-8
Cline, J M; Hughes Jr, C L (1998) Phytochemicals for the prevention of breast and endometrial cancer. Cancer Treat Res 94:107-34
Foth, D; Cline, J M (1998) Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. Am J Clin Nutr 68:1413S-1417S
O'Sullivan, M G; Anderson, D K; Goodrich, J A et al. (1997) Experimental infection of cynomolgus monkeys with simian parvovirus. J Virol 71:4517-21
Clarkson, T B; Cline, J M; Williams, J K et al. (1997) Gonadal hormone substitutes: effects on the cardiovascular system. Osteoporos Int 7 Suppl 1:S43-51

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