The long term aim of this project is to take emerging methods from computer graphics and extend state of the art in data collection, modeling, analysis and visualization of three-dimensional brain structures. The intent is to develop new algorithms and create a set of modular and re-usable tools for collect and interacting with multivalued anatomic information, as well as developing tools that aid in dissemination of this information. By developing new types of computation, the intent is to ultimately enable new types of diagnostic procedures and approaches for use by brain researchers and health practitioners. There are five related research areas in this project: 1) continued development of """"""""goal-based"""""""" data acquisition methods, 2) elucidation of microstructure from diffusion tensor data, 3) multivalued tissue classification algorithms, 4) semi-immersive visualization algorithms and interaction methods for display and data acquisition on a """"""""Responsive Workbench"""""""" and 5) new types of multivalued visualization methods, such as """"""""painterly"""""""" visualization. The project involves magnetic resonance micro-imaging, and two-photon and confocal microscopy. Using high resolution anatomical data from the Atlas Project and MRI Core and optical data from the Connectivity Project, tissues will be classified and visualized through their chemical composition and microstructure. The algorithms and an annotated subsets of the visualized data will be disseminated through publications and via the web.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA008944-09
Application #
6493311
Study Section
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
9
Fiscal Year
2001
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Martin, Melanie; Hiltner, Timothy D; Wood, John C et al. (2006) Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res 84:1716-26
Alauddin, Mian M; Louie, Angelique Y; Shahinian, Antranik et al. (2003) Receptor mediated uptake of a radiolabeled contrast agent sensitive to beta-galactosidase activity. Nucl Med Biol 30:261-5
Dhenain, Marc; Privat, Nicolas; Duyckaerts, Charles et al. (2002) Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed 15:197-203
Sendhil Velan, S; Narasimhan, P T; Jacobs, R E (2001) MR imaging with phase encoding of intermolecular multiple quantum coherences. J Magn Reson 152:189-94
Ahrens, E T; Dubowitz, D J (2001) Peripheral somatosensory fMRI in mouse at 11.7 T. NMR Biomed 14:318-24
Neusch, C; Rozengurt, N; Jacobs, R E et al. (2001) Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci 21:5429-38
Holbrook, N M; Ahrens, E T; Burns, M J et al. (2001) In vivo observation of cavitation and embolism repair using magnetic resonance imaging. Plant Physiol 126:27-31
Dhenain, M; Ruffins, S W; Jacobs, R E (2001) Three-dimensional digital mouse atlas using high-resolution MRI. Dev Biol 232:458-70
Allman, J; Hasenstaub, A (1999) Brains, maturation times, and parenting. Neurobiol Aging 20:447-54