Large national biomonitoring studies are reporting nearly universal exposure to numerous environmental contaminants in the US population, including Bisphenol A, raising the question of how exactly people are being exposed. Identifying the actual sources of exposure to chemicals that are ubiquitous in our environment is fundamental to the development of strategies and policies that will effectively reduce and prevent harmful exposures. Our understanding of human contact with environmental sources of exposure is inadequately characterized and thus we do not know which sources or behaviors are producing the chemical body burden that we discover through biomonitoring studies. This pilot study is designed to provide original research on potential sources of exposure to BPA and to help resolve the current debate regarding the biological half-life of BPA and to provide critical insights into potential sources of fetal exposure to BPA, a lifestage at high risk. To achieve these aims, we will develop and implement a questionnaire on dietary intake of potentially BPA contaminated foods and beverages. We will analyze the relationship between questionnaire data and levels of BPA measured in biological specimens from pregnant women to identify key sources of exposure. We will also explore and account for previously reported relationships between BPA exposure and such socio-demographic factors as age, ethnicity and socio-economic status. We will compare levels of BPA in maternal specimens collected during non-fasting and fasting conditions to characterize the clearance and biological half life of BPA in pregnant women. This study addresses data gaps in our knowledge of how humans are exposed to BPA - a key piece of information for reducing and preventing exposures. It will also provide valuable insight regarding the biological half-life of BPA. This informaiton will contribute to efforts toward prevention of exposures and will contribute new tools to future epidemiologic studies.

Public Health Relevance

This study will identify sources of BPA and how these contribute to measured levels of BPA in pregnant women. It will also provide information about whether reducing BPA exposure through food will contribute to declines in BPA levels measured in pregnant women.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory Grants (P20)
Project #
5P20ES018135-02
Application #
8225474
Study Section
Special Emphasis Panel (ZES1)
Project Start
2011-02-01
Project End
2013-01-31
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
2
Fiscal Year
2011
Total Cost
$27,032
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Gerona, Roy R; Schwartz, Jackie M; Pan, Janet et al. (2018) Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry. J Expo Sci Environ Epidemiol 28:101-108
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2016) Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environ Health 15:43
Morgan, Rebecca L; Thayer, Kristina A; Bero, Lisa et al. (2016) GRADE: Assessing the quality of evidence in environmental and occupational health. Environ Int 92-93:611-6
Vandenberg, Laura N; Ă…gerstrand, Marlene; Beronius, Anna et al. (2016) A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environ Health 15:74
Gerona, Roy R; Pan, Janet; Zota, Ami R et al. (2016) Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environ Health 15:50
Stotland, Naomi E; Sutton, Patrice; Trowbridge, Jessica et al. (2014) Counseling patients on preventing prenatal environmental exposures--a mixed-methods study of obstetricians. PLoS One 9:e98771
Koustas, Erica; Lam, Juleen; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015-27
Johnson, Paula I; Sutton, Patrice; Atchley, Dylan S et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1028-39
Vandenberg, Laura N; Gerona, Roy R; Kannan, Kurunthachalam et al. (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13:25
Lam, Juleen; Koustas, Erica; Sutton, Patrice et al. (2014) The Navigation Guide - evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1040-51

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