? Bioinformatics Core Bioinformatics now plays a central role in supporting research in biomedical and all life sciences; data-intensive research methodologies like RNA sequencing have become foundational techniques. The researchers of today must have a grasp of the concepts for how these technologies can advance their research. To support the growing and diversified informatics needs, bioinformatics cores have to evolve to not only provide computational infrastructure and the expertise to perform high-throughput data analysis, but also increasingly to serve as centers of education driving the training of informatically savvy researchers who can effectively utilize and interpret the data. Having built strong foundations for bioinformatics resources in Delaware under previous DE-INBRE funding cycles, the Bioinformatics Core will further expand its reach and impact throughout the State. The DE-INBRE Bioinformatics Core is organized as a Bioinformatics Network of Delaware (BiND) with a Steering Committee that includes representatives from all Partner Institutions to help guide and shape Delaware INBRE?s bioinformatics initiatives and create synergies to meet the evolving needs of the program. In particular, DE-INBRE IV will increase accessibility of bioinformatics resources and expertise currently concentrated at University of Delaware (UD), bio-imaging and computational neuroscience at Delaware State University (DSU), and biomedical and clinical informatics resources housed at Nemours/Alfred I. duPont Hospital for Children (Nemours) and Christiana Care Health System (CCHS) among the DE-INBRE Partner Institutions to provide the informatics cyberinfrastructure, research support, educational programs, and research exposures needed to promote a vibrant biomedical research capacity in the State of Delaware.
Specific Aims 1. Support DE-INBRE?s expanded Biomedical Research Network. 2. Enhance Delaware?s biomedical research capacity. 3. Support biomedical research initiatives in Delaware. 4. Enhance the science and technology knowledge of Delaware?s workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103446-19
Application #
9672739
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
19
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Bialk, Pawel; Wang, Yichen; Banas, Kelly et al. (2018) Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model. Mol Ther Oncolytics 11:75-89
Bhattacharya, Moumita; Jurkovitz, Claudine; Shatkay, Hagit (2018) Chronic Kidney Disease stratification using office visit records: Handling data imbalance via hierarchical meta-classification. BMC Med Inform Decis Mak 18:125
Kao, Chen-Yuan; Papoutsakis, Eleftherios T (2018) Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells. Sci Adv 4:eaau6762
McAllister, Sean M; Moore, Ryan M; Chan, Clara S (2018) ZetaHunter, a Reproducible Taxonomic Classification Tool for Tracking the Ecology of the Zetaproteobacteria and Other Poorly Resolved Taxa. Microbiol Resour Announc 7:
Haider, Michael J; Zhang, Huixi Violet; Sinha, Nairiti et al. (2018) Self-assembly and soluble aggregate behavior of computationally designed coiled-coil peptide bundles. Soft Matter 14:5488-5496
McIlvain, Grace; Schwarb, Hillary; Cohen, Neal J et al. (2018) Mechanical properties of the in vivo adolescent human brain. Dev Cogn Neurosci 34:27-33
Greene, Daniel G; Traylor, Steven J; Guo, Jing et al. (2018) Mechanisms of precipitate formation during the purification of an Fc-fusion protein. Biotechnol Bioeng 115:2489-2503
Hilzinger, Jacob M; Raman, Vidhyavathi; Shuman, Kevin E et al. (2018) Differential RNA Sequencing Implicates Sulfide as the Master Regulator of S0 Metabolism in Chlorobaculum tepidum and Other Green Sulfur Bacteria. Appl Environ Microbiol 84:
Allgood, Samual C; Neunuebel, M Ramona (2018) The recycling endosome and bacterial pathogens. Cell Microbiol 20:e12857
Franke, Karl R; Schmidt, Skye A; Park, Sunhee et al. (2018) Analysis of Brachypodium miRNA targets: evidence for diverse control during stress and conservation in bioenergy crops. BMC Genomics 19:547

Showing the most recent 10 out of 333 publications