? Bioinformatics Core Bioinformatics now plays a central role in supporting research in biomedical and all life sciences; data-intensive research methodologies like RNA sequencing have become foundational techniques. The researchers of today must have a grasp of the concepts for how these technologies can advance their research. To support the growing and diversified informatics needs, bioinformatics cores have to evolve to not only provide computational infrastructure and the expertise to perform high-throughput data analysis, but also increasingly to serve as centers of education driving the training of informatically savvy researchers who can effectively utilize and interpret the data. Having built strong foundations for bioinformatics resources in Delaware under previous DE-INBRE funding cycles, the Bioinformatics Core will further expand its reach and impact throughout the State. The DE-INBRE Bioinformatics Core is organized as a Bioinformatics Network of Delaware (BiND) with a Steering Committee that includes representatives from all Partner Institutions to help guide and shape Delaware INBRE?s bioinformatics initiatives and create synergies to meet the evolving needs of the program. In particular, DE-INBRE IV will increase accessibility of bioinformatics resources and expertise currently concentrated at University of Delaware (UD), bio-imaging and computational neuroscience at Delaware State University (DSU), and biomedical and clinical informatics resources housed at Nemours/Alfred I. duPont Hospital for Children (Nemours) and Christiana Care Health System (CCHS) among the DE-INBRE Partner Institutions to provide the informatics cyberinfrastructure, research support, educational programs, and research exposures needed to promote a vibrant biomedical research capacity in the State of Delaware.
Specific Aims 1. Support DE-INBRE?s expanded Biomedical Research Network. 2. Enhance Delaware?s biomedical research capacity. 3. Support biomedical research initiatives in Delaware. 4. Enhance the science and technology knowledge of Delaware?s workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103446-20
Application #
9930650
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
20
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Modarai, Shirin R; Man, Dula; Bialk, Pawel et al. (2018) Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex. Mol Ther Nucleic Acids 11:116-129
Tantzer, Stephanie; Sperle, Karen; Kenaley, Kaitlin et al. (2018) Morpholino Antisense Oligomers as a Potential Therapeutic Option for the Correction of Alternative Splicing in PMD, SPG2, and HEMS. Mol Ther Nucleic Acids 12:420-432
Francis, Felix; Dumas, Michael D; Davis, Scott B et al. (2018) Clustering of circular consensus sequences: accurate error correction and assembly of single molecule real-time reads from multiplexed amplicon libraries. BMC Bioinformatics 19:302
Yu, Xiaobo; Noll, Rebecca R; Romero DueƱas, Barbara P et al. (2018) Legionella effector AnkX interacts with host nuclear protein PLEKHN1. BMC Microbiol 18:5
Brescia, AnneMarie C; Simonds, Megan M; McCahan, Suzanne M et al. (2018) Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable. Pediatr Rheumatol Online J 16:3
Johnson, Curtis L; Telzer, Eva H (2018) Magnetic resonance elastography for examining developmental changes in the mechanical properties of the brain. Dev Cogn Neurosci 33:176-181
Rupp, Oliver; MacDonald, Madolyn L; Li, Shangzhong et al. (2018) A reference genome of the Chinese hamster based on a hybrid assembly strategy. Biotechnol Bioeng 115:2087-2100
Doshi, Sagar M; Thostenson, Erik T (2018) Thin and Flexible Carbon Nanotube-Based Pressure Sensors with Ultrawide Sensing Range. ACS Sens 3:1276-1282
Melamed, Jilian R; Kreuzberger, Nicole L; Goyal, Ritu et al. (2018) Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery. Mol Ther Nucleic Acids 12:207-219
D'Souza, Malcolm J; Shuman, Kevin E; Wentzien, Derald E et al. (2018) Working with the Wesley College Cannon Scholar Program: Improving Retention, Persistence, and Success. J STEM Educ 19:31-40

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