Oklahoma's IDeA Network for Biomedical Research Excellence (INBRE) will enhance statewide research infrastructure and capacity for biomedical research by 1) Supporting the research career development of promising investigators through direct support of their research, 2) Enhancing the pipeline of undergraduate students entering graduate programs by support of student training initiatives at primarily undergraduate institutions (PUIs), community colleges (CCs), and the pre-college level, 3) Providing a core facility network that supports both the research of the INBRE investigators and the statewide biomedical research effort, and 4) Enhancing the science and technology knowledge of the state's workforce. The Oklahoma INBRE Network comprises two research-intensive institutions, The University of Oklahoma Health Sciences Center (OUHSC) and the Oklahoma Medical Research Foundation (OMRF), whose primary missions are biomedical research, education, and patient care. These institutions are intimately coupled with six PUIs and four CCs that are essential to the success of the INBRE network. The statewide INBRE network includes Oklahoma's only Historically Black University, a PUI with the highest number of American Indians of any four year college in the nation, Oklahoma's largest tribal college, as well as other PUIs and CCs with large numbers of students from underrepresented groups. The scientific research themes are multi-disciplinary and span the areas of Cancer, Developmental Biology, and Microbiology & Immunology. INBRE will support with significant resources eight Research Project Investigators (RPIs) in the three scientific themes, four from OUHSC/OMRF and four from the network PUIs. Specific mentoring and career development advice from a senior investigator mentoring committee for each scientific theme will help to guide the RPIs into independently funded research careers. In addition, 10 grant awards for research and equipment also will be provided to the PUIs through an annual competition. Support for undergraduate students will be provided by INBRE summer internships (20 for the PUIs and 15 for the CCs). INBRE also will support a Bioinformatics Core facility at OUHSC that will provide a statewide bioinformatics research resource, coupling this with educational outreach and course development for the INBRE network PUIs and CCs. Building on past success, INBRE support for faculty and student research, core facilities, and educational outreach will continue to enhance the student biomedical research pipeline, the knowledge of science and technology in the state's workforce, and stimulate Oklahoma to become nationally competitive in biomedical research.

Public Health Relevance

Infectious diseases, cancer, and developmental biology syndromes are important public health priorities. Biomedical research in these broad scientific areas and understanding how they relate to human health and disease requires building more research infrastructure and capacity. Through the large and dynamic INBRE biomedical research network in Oklahoma, we are enhancing the current and future biomedical research workforce and infrastructure in these specific areas to improve public health for future generations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
3P20GM103447-17S1
Application #
9317705
Study Section
Special Emphasis Panel (ZGM1-TWD-3 (IN))
Program Officer
Douthard, Regine
Project Start
2001-09-06
Project End
2019-04-30
Budget Start
2016-05-03
Budget End
2017-04-30
Support Year
17
Fiscal Year
2016
Total Cost
$493,475
Indirect Cost
$72,049
Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Hardy, Rachel N; Simsek, Zinar D; Curry, Brandon et al. (2018) Aging affects isoproterenol-induced water drinking, astrocyte density, and central neuronal activation in female Brown Norway rats. Physiol Behav 192:90-97
Masilamani, Revathi; Cian, Melina B; Dalebroux, Zachary D (2018) Salmonella Tol-Pal Reduces Outer Membrane Glycerophospholipid Levels for Envelope Homeostasis and Survival during Bacteremia. Infect Immun 86:
Benbrook, Doris M; Janakiram, Naveena B; Chandra, Vishal et al. (2018) Development of a dietary formulation of the SHetA2 chemoprevention drug for mice. Invest New Drugs 36:561-570
Seshadri, Sudarshan; Pope, Rosemary L; Zenewicz, Lauren A (2018) Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production. J Immunol 201:1267-1274
Budda, Scott A; Zenewicz, Lauren A (2018) IL-22 deficiency increases CD4 T cell responses to mucosal immunization. Vaccine 36:3694-3700
Yen, Ting-An; Dahal, Kaushalya Sharma; Lavine, Barry et al. (2018) Development and Validation of High Performance Liquid Chromatographic Method for Determination of Gentisic Acid and Related Renal Cell Carcinoma Biomarkers in Urine. Microchem J 137:85-89
Khandaker, Morshed; Riahinezhad, Shahram; Sultana, Fariha et al. (2018) Effect of Collagen-Polycaprolactone Nanofibers Matrix Coating on the In Vitro Cytocompatibility and In Vivo Bone Responses of Titanium. J Med Biol Eng 38:197-210
Rao, Chinthalapally V; Farooqui, Mudassir; Zhang, Yuting et al. (2018) Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell :e12797
Borga, Chiara; Park, Gilseung; Foster, Clay et al. (2018) Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia :
Lahousse, Mieke; Park, Hae-Chul; Lee, Sang-Choon et al. (2018) Inhibition of anthrax lethal factor by ssDNA aptamers. Arch Biochem Biophys 646:16-23

Showing the most recent 10 out of 93 publications