Abstract

. NGS technologies have transformed the way in which research is conducted. The sheer scale of inquiry has been expanded to the extent that whole genomes and transcriptomes of cohorts of individuals can be surveyed in a single experiment. Moreover, sequencing can be used to probe biological phenomena at multiple levels of regulation, including germ-line variation, DNA methylation, mRNA expression and splice form abundance, microRNA expression, and chromatin structure exploration. NGS is also displacing other technologies, in particular the use of fixed-content chips for genotyping. NGS is being applied in every field of biological research, and will be an essential tool in the development of individualized medicine. Sequence data without sophisticated bioinformatics is essentially useless. Having a technology partner consisting of an experienced team of bioinformatics researchers and analysts, co-located with the sequencing operation is unprecedented in New Mexico. The SBC will continue to provide the network turn-key access to discovery? enabling sequencing and bioinformatics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103451-17
Application #
9249599
Study Section
Special Emphasis Panel (ZGM1-TWD-3)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
17
Fiscal Year
2017
Total Cost
$743,981
Indirect Cost
$88,320

  Institution

Name
New Mexico State University Las Cruces
Department
Type
Domestic Higher Education
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003

  Publications

Niroula, Doleshwar; Hallada, Liam P; Le Chapelain, Camille et al. (2018) Design, synthesis, and evaluation of cystargolide-based ?-lactones as potent proteasome inhibitors. Eur J Med Chem 157:962-977
Yan, Hao; Bhattarai, Umesh; Song, Yabin et al. (2018) Design, synthesis and activity of light deactivatable microRNA inhibitor. Bioorg Chem 80:492-497
Zhong, Hua; Song, Mingzhou (2018) A fast exact functional test for directional association and cancer biology applications. IEEE/ACM Trans Comput Biol Bioinform :
Nemunaitis, Jacklyn M; Brown-Glabeman, Ursa; Soares, Heloisa et al. (2018) Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico. BMC Cancer 18:665
Sheng, Haiqing; Duan, Mingrui; Hunter, Samuel S et al. (2018) High-Quality Complete Genome Sequences of Three Bovine Shiga Toxin-ProducingEscherichia coliO177:H- (fliCH25) Isolates Harboring Virulentstx2and Multiple Plasmids. Genome Announc 6:
Dominguez, Matthew J; Lantz, Benjamin J; Rhode, Rebecca J et al. (2018) A multi-column plate adapter provides an economical and versatile high-throughput protein purification system. Protein Expr Purif 152:84-91
DeVore, Stanley B; Young, Coleman H; Li, Guangyuan et al. (2018) Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells. Mol Cell Biol :
Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934
Gautam, Gayatri P; Gurung, Rubi; Fencl, Frank A et al. (2018) Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis. Anal Bioanal Chem 410:6561-6571
Brown, Tom; Brown, Nick; Stollar, Elliott J (2018) Most yeast SH3 domains bind peptide targets with high intrinsic specificity. PLoS One 13:e0193128

Showing the most recent 10 out of 156 publications