Abstract

. NGS technologies have transformed the way in which research is conducted. The sheer scale of inquiry has been expanded to the extent that whole genomes and transcriptomes of cohorts of individuals can be surveyed in a single experiment. Moreover, sequencing can be used to probe biological phenomena at multiple levels of regulation, including germ-line variation, DNA methylation, mRNA expression and splice form abundance, microRNA expression, and chromatin structure exploration. NGS is also displacing other technologies, in particular the use of fixed-content chips for genotyping. NGS is being applied in every field of biological research, and will be an essential tool in the development of individualized medicine. Sequence data without sophisticated bioinformatics is essentially useless. Having a technology partner consisting of an experienced team of bioinformatics researchers and analysts, co-located with the sequencing operation is unprecedented in New Mexico. The SBC will continue to provide the network turn-key access to discovery? enabling sequencing and bioinformatics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103451-17
Application #
9249599
Study Section
Special Emphasis Panel (ZGM1-TWD-3)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
17
Fiscal Year
2017
Total Cost
$743,981
Indirect Cost
$88,320

  Institution

Name
New Mexico State University Las Cruces
Department
Type
Domestic Higher Education
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003

  Publications

Gautam, Gayatri P; Gurung, Rubi; Fencl, Frank A et al. (2018) Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis. Anal Bioanal Chem 410:6561-6571
Brown, Tom; Brown, Nick; Stollar, Elliott J (2018) Most yeast SH3 domains bind peptide targets with high intrinsic specificity. PLoS One 13:e0193128
Joseph, Braveen B; Blouin, Nicolas A; Fay, David S (2018) Use of a Sibling Subtraction Method for Identifying Causal Mutations in Caenorhabditis elegans by Whole-Genome Sequencing. G3 (Bethesda) 8:669-678
He, Jingxuan; Melançon 3rd, Charles E (2018) Genetic Incorporation of Unnatural Amino Acids into Proteins of Interest in Streptomyces venezuelae ATCC 15439. Methods Mol Biol 1728:155-168
Edwards, Leslie; Turner, Danielle; Champion, Cody et al. (2018) Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria. Bioorg Med Chem Lett 28:1879-1886
Maslivetc, Vladimir A; Turner, Danielle N; McNair, Kimberly N et al. (2018) Desymmetrization of Cyclopropenes via the Potassium-Templated Diastereoselective 7- exo- trig Cycloaddition of Tethered Amino Alcohols toward Enantiopure Cyclopropane-Fused Oxazepanones with Antimycobacterial Activity. J Org Chem 83:5650-5664
Gautam, Gayatri P; Burger, Tobias; Wilcox, Andrew et al. (2018) Simple and inexpensive micromachined aluminum microfluidic devices for acoustic focusing of particles and cells. Anal Bioanal Chem 410:3385-3394
Martin, David R; LaBauve, Elisa; Pomo, Joseph M et al. (2018) Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression. Pancreas 47:502-510
Rubasinghege, Gayan; Gurung, Rubi; Rijal, Hom et al. (2018) Abiotic degradation and environmental toxicity of ibuprofen: Roles of mineral particles and solar radiation. Water Res 131:22-32
Dotson, Rachel J; Pias, Sally C (2018) Reduced Oxygen Permeability upon Protein Incorporation Within Phospholipid Bilayers. Adv Exp Med Biol 1072:405-411

Showing the most recent 10 out of 156 publications