Abstract

The Physiologic Core (C) will be located in the Division of Animal Laboratory Resources within dedicated space at the University of Kentucky. This core will provide equipment, services and training for quantifying cardiovascular, diabetes, and obesity phenotypes. This includes measurement of atherosclerosis, quantifying sera lipoprotein cholesterol, ultrasound for assessing vascular and cardiac function, MRI for analyzing cardiac function and fat deposifion, and tail cuff and radiotelemetry platforms to quantify blood pressure. For diabetes, this includes training and service in performing glucose and insulin tolerance tests in mice, and for small scale studies using euglycemic hyperinsulinemic clamps in mice. For obesity, this includes echoMRI to quantify fat/lean mass, TSE LabMaster chambers to quantify food/water intake, physical activity and indirect calorimetry, and PhenoMaster chambers for urine/feces collection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
4P20GM103527-09
Application #
9135487
Study Section
Special Emphasis Panel (ZGM1-TWD-Y)
Project Start
Project End
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
9
Fiscal Year
2016
Total Cost
$188,700
Indirect Cost
$63,318

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Stewart, Bradley D; Scott, Caitlin E; McCoy, Thomas P et al. (2018) Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes. Cell Calcium 71:65-74
Rotroff, Daniel M; Pijut, Sonja S; Marvel, Skylar W et al. (2018) Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. Clin Pharmacol Ther 103:712-721
Thompson, Joel C; Wilson, Patricia G; Shridas, Preetha et al. (2018) Serum amyloid A3 is pro-atherogenic. Atherosclerosis 268:32-35
Klyachkin, Yuri M; Idris, Amr; Rodell, Christopher B et al. (2018) Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. Stem Cell Rev 14:702-714
Alshudukhi, Abdullah A; Zhu, Jing; Huang, Dengtong et al. (2018) Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. FASEB J :fj201800374
Wang, Fang; Liu, Zun; Park, Se-Hyung et al. (2018) Myeloid ?-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol 38:1468-1478
Finlin, Brian S; Memetimin, Hasiyet; Confides, Amy L et al. (2018) Human adipose beiging in response to cold and mirabegron. JCI Insight 3:
Dong, Lixn; Ren, Hongmei (2018) Blood-based DNA Methylation Biomarkers for Early Detection of Colorectal Cancer. J Proteomics Bioinform 11:120-126
Adamiak, Mateusz; Bujko, Kamila; Cymer, Monika et al. (2018) Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. Leukemia 32:1920-1931
Manning, Janet R; Chelvarajan, Lakshman; Levitan, Bryana M et al. (2018) Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling. JACC Basic Transl Sci 3:83-96

Showing the most recent 10 out of 235 publications