Abstract

Gait impairments are a core feature in Parkinson?s disease and patients become more visually dependent to compensate for their motor deficits. Yet, visual disturbances are a common, but often overlooked problem in Parkinson?s disease, that may lead to unsafe locomotion. To navigate efficiently through complex real-world environments, eye movements need to be attuned to the locomotor task. Gaze anticipation during walking and turning is critical for motor anticipation, and contributes to the spatial perception during motion. The overall goal of this project is to characterize how gaze is attenuated to different aspect of the environment and how visual function relates to dynamic stability during walking in complex real-world settings.
The specific aims are: I. To determine the effect of path complexity on visual control of locomotion. II. To determine the effect of medication state on visual control of locomotion. III. To investigate how cognition is related to visual control of locomotion. Building upon technological advances, this project aims to determine the contribution of visual function and cognition on gait outcomes in people with Parkinson's disease in complex real-world settings with the goal to inform future interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109090-07
Application #
10230931
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Davani, Behrous
Project Start
2020-04-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Omaha
Department
Type
DUNS #
190827162
City
Omaha
State
NE
Country
United States
Zip Code
68182

  Publications

Rand, Troy J; Mukherjee, Mukul (2018) Transitions in persistence of postural dynamics depend on the velocity and structure of postural perturbations. Exp Brain Res 236:1491-1500
Groff, Boman R; Antonellis, Prokopios; Schmid, Kendra K et al. (2018) Stride-time variability is related to sensorimotor cortical activation during forward and backward walking. Neurosci Lett 692:150-158
Zuniga, Jorge M; Dimitrios, Katsavelis; Peck, Jean L et al. (2018) Coactivation index of children with congenital upper limb reduction deficiencies before and after using a wrist-driven 3D printed partial hand prosthesis. J Neuroeng Rehabil 15:48
Mukherjee, M; Yentes, J M (2018) Movement variability: A perspective on success in sports, health, and life. Scand J Med Sci Sports 28:758-759
Hernandez, Hernan; Myers, Sara A; Schieber, Molly et al. (2018) Quantification of Daily Physical Activity and Sedentary Behavior of Claudicating Patients. Ann Vasc Surg :
Raffalt, Peter C; McCamley, John; Denton, William et al. (2018) Sampling frequency influences sample entropy of kinematics during walking. Med Biol Eng Comput :
Dutt-Mazumder, Aviroop; Rand, Troy J; Mukherjee, Mukul et al. (2018) Scaling oscillatory platform frequency reveals recurrence of intermittent postural attractor states. Sci Rep 8:11580
Rock, Chase G; Marmelat, Vivien; Yentes, Jennifer M et al. (2018) Interaction between step-to-step variability and metabolic cost of transport during human walking. J Exp Biol 221:
McCamley, John D; Cutler, Eric L; Schmid, Kendra K et al. (2018) Gait Mechanics Differences Between Healthy Controls and Patients With Peripheral Artery Disease After Adjusting for Gait Velocity Stride Length and Step Width. J Appl Biomech :1-19
Grindle, Daniel M; Baker, Lauren; Furr, Mike et al. (2018) The Effects of Walking Workstations on Biomechanical Performance. J Appl Biomech 34:349-353

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