Abstract

Gait impairments are a core feature in Parkinson?s disease and patients become more visually dependent to compensate for their motor deficits. Yet, visual disturbances are a common, but often overlooked problem in Parkinson?s disease, that may lead to unsafe locomotion. To navigate efficiently through complex real-world environments, eye movements need to be attuned to the locomotor task. Gaze anticipation during walking and turning is critical for motor anticipation, and contributes to the spatial perception during motion. The overall goal of this project is to characterize how gaze is attenuated to different aspect of the environment and how visual function relates to dynamic stability during walking in complex real-world settings.
The specific aims are: I. To determine the effect of path complexity on visual control of locomotion. II. To determine the effect of medication state on visual control of locomotion. III. To investigate how cognition is related to visual control of locomotion. Building upon technological advances, this project aims to determine the contribution of visual function and cognition on gait outcomes in people with Parkinson's disease in complex real-world settings with the goal to inform future interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109090-07
Application #
10230931
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Davani, Behrous
Project Start
2020-04-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Omaha
Department
Type
DUNS #
190827162
City
Omaha
State
NE
Country
United States
Zip Code
68182

  Publications

Yentes, Jennifer M; Denton, William; McCamley, John et al. (2018) Effect of parameter selection on entropy calculation for long walking trials. Gait Posture 60:128-134
Ray, Samuel F; Wurdeman, Shane R; Takahashi, Kota Z (2018) Prosthetic energy return during walking increases after 3 weeks of adaptation to a new device. J Neuroeng Rehabil 15:6
Bruening, Dustin A; Takahashi, Kota Z (2018) Partitioning ground reaction forces for multi-segment foot joint kinetics. Gait Posture 62:111-116
Raffalt, P C; Yentes, J M (2018) Introducing Statistical Persistence Decay: A Quantification of Stride-to-Stride Time Interval Dependency in Human Gait. Ann Biomed Eng 46:60-70
Marmelat, Vivien; Reynolds, Nicholas R; Hellman, Amy (2018) Gait Dynamics in Parkinson's Disease: Short Gait Trials ""Stitched"" Together Provide Different Fractal Fluctuations Compared to Longer Trials. Front Physiol 9:861
Rand, Troy J; Ambati, Venkata Naga Pradeep; Mukherjee, Mukul (2018) Persistence in postural dynamics is dependent on constraints of vision, postural orientation, and the temporal structure of support surface translations. Exp Brain Res :
Yentes, Jennifer M; Denton, William; Samson, Kaeli et al. (2018) Energy efficient physiologic coupling of gait and respiration is altered in chronic obstructive pulmonary disease. Acta Physiol (Oxf) :e13217
Huang, Chun-Kai; Shivaswamy, Vijay; Thaisetthawatkul, Pariwat et al. (2018) An altered spatiotemporal gait adjustment during a virtual obstacle crossing task in patients with diabetic peripheral neuropathy. J Diabetes Complications :
Ebrahimi, Anahid; Collins, John D; Kepple, Thomas M et al. (2018) A mathematical analysis to address the 6 degree-of-freedom segmental power imbalance. J Biomech 66:186-193
Malcolm, Philippe; Galle, Samuel; Van den Berghe, Pieter et al. (2018) Exoskeleton assistance symmetry matters: unilateral assistance reduces metabolic cost, but relatively less than bilateral assistance. J Neuroeng Rehabil 15:74

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