Gait impairments are a core feature in Parkinson?s disease and patients become more visually dependent to compensate for their motor deficits. Yet, visual disturbances are a common, but often overlooked problem in Parkinson?s disease, that may lead to unsafe locomotion. To navigate efficiently through complex real-world environments, eye movements need to be attuned to the locomotor task. Gaze anticipation during walking and turning is critical for motor anticipation, and contributes to the spatial perception during motion. The overall goal of this project is to characterize how gaze is attenuated to different aspect of the environment and how visual function relates to dynamic stability during walking in complex real-world settings.
The specific aims are: I. To determine the effect of path complexity on visual control of locomotion. II. To determine the effect of medication state on visual control of locomotion. III. To investigate how cognition is related to visual control of locomotion. Building upon technological advances, this project aims to determine the contribution of visual function and cognition on gait outcomes in people with Parkinson's disease in complex real-world settings with the goal to inform future interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109090-07
Application #
10230931
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Davani, Behrous
Project Start
2020-04-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Nebraska Omaha
Department
Type
DUNS #
190827162
City
Omaha
State
NE
Country
United States
Zip Code
68182
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