Abstract

Gait impairments are a core feature in Parkinson?s disease and patients become more visually dependent to compensate for their motor deficits. Yet, visual disturbances are a common, but often overlooked problem in Parkinson?s disease, that may lead to unsafe locomotion. To navigate efficiently through complex real-world environments, eye movements need to be attuned to the locomotor task. Gaze anticipation during walking and turning is critical for motor anticipation, and contributes to the spatial perception during motion. The overall goal of this project is to characterize how gaze is attenuated to different aspect of the environment and how visual function relates to dynamic stability during walking in complex real-world settings.
The specific aims are: I. To determine the effect of path complexity on visual control of locomotion. II. To determine the effect of medication state on visual control of locomotion. III. To investigate how cognition is related to visual control of locomotion. Building upon technological advances, this project aims to determine the contribution of visual function and cognition on gait outcomes in people with Parkinson's disease in complex real-world settings with the goal to inform future interventions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109090-07
Application #
10230931
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Davani, Behrous
Project Start
2020-04-01
Project End
2024-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Nebraska Omaha
Department
Type
DUNS #
190827162
City
Omaha
State
NE
Country
United States
Zip Code
68182

  Publications

Malcolm, Philippe; Galle, Samuel; Van den Berghe, Pieter et al. (2018) Exoskeleton assistance symmetry matters: unilateral assistance reduces metabolic cost, but relatively less than bilateral assistance. J Neuroeng Rehabil 15:74
Bruening, Dustin A; Pohl, Michael B; Takahashi, Kota Z et al. (2018) Midtarsal locking, the windlass mechanism, and running strike pattern: A kinematic and kinetic assessment. J Biomech 73:185-191
Kempski, Kelley; Awad, Louis N; Buchanan, Thomas S et al. (2018) Dynamic structure of lower limb joint angles during walking post-stroke. J Biomech 68:1-5
Haworth, Joshua; Stergiou, Nicholas (2018) Orderliness of Visual Stimulus Motion Mediates Sensorimotor Coordination. Front Physiol 9:1441
Childers, W Lee; Takahashi, Kota Z (2018) Increasing prosthetic foot energy return affects whole-body mechanics during walking on level ground and slopes. Sci Rep 8:5354
Leeder, Taylor; Fallahtafti, Farahnaz; Schieber, Molly et al. (2018) Optic flow improves step width and length in older adults while performing dual task. Aging Clin Exp Res :
Lanier, Amelia S; Knarr, Brian A; Stergiou, Nicholas et al. (2018) A Novel and Safe Approach to Simulate Cutting Movements Using Ground Reaction Forces. Sensors (Basel) 18:
Ray, Nicole T; Knarr, Brian A; Higginson, Jill S (2018) Walking speed changes in response to novel user-driven treadmill control. J Biomech 78:143-149
Rand, Troy J; Mukherjee, Mukul (2018) Transitions in persistence of postural dynamics depend on the velocity and structure of postural perturbations. Exp Brain Res 236:1491-1500
Groff, Boman R; Antonellis, Prokopios; Schmid, Kendra K et al. (2018) Stride-time variability is related to sensorimotor cortical activation during forward and backward walking. Neurosci Lett 692:150-158

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