The overall goal of the Administrative Core of the WVU Stroke CoBRE is to provide leadership and manage the development of a center of excellence in basic and translational stroke research at West Virginia University (WVU). To achieve this goal, the following specific aims will be achieved: The thematic research focus area is stroke and the research projects assess linked areas of the prediction, causes, acute treatment and rehabilitation of stroke. To achieve this goal, the follow specific aims will be achieved:
Specific Aim 1 : Develop high quality mentored research and career development in the WVU Stroke CoBRE. All five research projects emanate from the research activities of assistant/associate professors in a tenure track appointment in their respective departments.
Aim 1 be achieved by expanding our mentoring program for junior faculty that addresses the transition to and attainment of independent research funding, with an emphasis on supporting the professional development of junior faculty. Clear expectations and milestones for mentees and their respective mentors (both internal and external) are highlighted in the annually signed mentoring agreement.
Specific Aim 2 : To hire new faculty with a research expertise in stroke. The Program Director and Internal Advisory Committee members are well positioned to direct recruitment of stroke researchers into new positions at WVU. Additionally, mid-funding cycle graduation of the current group of junior investigators will free up funds to provide startup packages for new recruits. These strategic appointments have already resulted in the active recruitment to WVU of 13 new faculty in stroke research in Phase I.
Specific Aim 3 : To continue a formative and summative evaluation strategy with specific milestones. Achieving these aims will launch the JIs as independent scientists in stroke research fields and provide a foundation of professional development for their long-term academic career success. Accomplishing these goals will position the WVU Stroke CoBRE to become a national center of excellence in stroke research that addresses the issue of stroke and its co-morbidities in West Virginia (WV) and the nation. The CoBRE mechanism will increase the number of stroke researchers, expand our capacity to programmatically address important issues in stroke and enhance our vital research cores that serve the stroke, cardiovascular and neuroscience communities at WVU and across the state while meeting the nation?s need for innovative approaches to this devastating disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM109098-06A1
Application #
10025929
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2014-09-08
Project End
2025-05-31
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
West Virginia University
Department
Type
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Sprenkle, Neil T; Lahiri, Anirudhya; Simpkins, James W et al. (2018) Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. J Neurochem :
O'Connell, Grant C; Treadway, Madison B; Tennant, Connie S et al. (2018) Shifts in Leukocyte Counts Drive the Differential Expression of Transcriptional Stroke Biomarkers in Whole Blood. Transl Stroke Res :
Brooks, Steven; Brnayan, Kayla W; DeVallance, Evan et al. (2018) Psychological stress-induced cerebrovascular dysfunction: the role of metabolic syndrome and exercise. Exp Physiol 103:761-776
Brichacek, Allison L; Brown, Candice M (2018) Alkaline phosphatase: a potential biomarker for stroke and implications for treatment. Metab Brain Dis :
Shumar, Stephanie A; Kerr, Evan W; Geldenhuys, Werner J et al. (2018) Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem 293:4134-4148
Tok, Fatih; Kocyigit-Kaymakcioglu, Bedia; Tabanca, Nurhayat et al. (2018) Synthesis and structure-activity relationships of carbohydrazides and 1,3,4-oxadiazole derivatives bearing an imidazolidine moiety against the yellow fever and dengue vector, Aedes aegypti. Pest Manag Sci 74:413-421
Popov, Anton; Olesh, Erienne V; Yakovenko, Sergiy et al. (2018) A novel method of identifying motor primitives using wavelet decomposition. Int Conf Wearable Implant Body Sens Netw 2018:122-125
DeVallance, Evan; Branyan, Kayla W; Lemaster, Kent et al. (2018) Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNF?- and NOX2-dependent pathway. Exp Physiol 103:590-603
Nair, Rajesh R; Geldenhuys, Werner J; Piktel, Debbie et al. (2018) Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia. Bioorg Med Chem Lett 28:1937-1942
Robinson, Andria R; Yousefzadeh, Matthew J; Rozgaja, Tania A et al. (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol 17:259-273

Showing the most recent 10 out of 61 publications