The COBRE in Cardiovascular Health brings together investigators from multiple disciplines focused on vascular aspects of cardiovascular health and will establish a new Cardiovascular Research Core at the University of Delaware (UD). The COBRE in Cardiovascular Health will capitalize on an emerging strength in cardiovascular research at UD creating a new signature COBRE, and researchers from multiple disciplines in the center will investigate the mechanisms, consequences, and potential interventions for declining cardiovascular health spanning basic, clinical/translational, and community based research to a degree that cannot be supported by existing instrumentation. Thus, this center will establish a Cardiovascular Research Core and support the established Delaware Biotechnology Institute (DBI) Bio-Imaging Core. These cores will provide resources for assessment of cardiovascular function and health, biostatistics, and bioimaging that will enhance cardiovascular research capabilities of the subproject investigators, as well other investigators in the center, university, and region. This establishment of a Cardiovascular Research Core (CVRC) will facilitate the assessment of cardiovascular function in rodents and humans. The CVRC will enable researchers to assess vascular function in rodents and humans, and ambulatory and central blood pressure in humans through the availability of instrumentation and personnel expertise. This core takes advantage of new facilities in the UD Health Sciences Complex and collaboration with the UD Nurse Managed Health Center. A plan for the establishment, oversight and maintenance of the CVRC is outlined. We will also support and expand existing DBI Bio-Imaging Core to facilitate the imaging of endothelial cells collected from human volunteers as well as vessels from rodent bone. We will expand the existing Bio-Imaging Center with the addition of a microscope slide scanner and imager for high throughput imaging of slides and provide support for Bio-Imaging personnel. A plan for oversight and maintenance is outlined.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM113125-01
Application #
8813033
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Patterson, Freda; Grandner, Michael A; Lozano, Alicia et al. (2018) Transitioning from adequate to inadequate sleep duration associated with higher smoking rate and greater nicotine dependence in a population sample. Addict Behav 77:47-50
Patterson, Freda; Lozano, Alicia; Huang, Liming et al. (2018) Towards a demographic risk profile for sedentary behaviours in middle-aged British adults: a cross-sectional population study. BMJ Open 8:e019639
Patterson, Freda; Malone, Susan Kohl; Grandner, Michael A et al. (2018) Interactive effects of sleep duration and morning/evening preference on cardiovascular risk factors. Eur J Public Health 28:155-161
Tremblay, Mark S; Aubert, Salomé; Barnes, Joel D et al. (2017) Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act 14:75
Lenhart, Clare M; Wiemken, Andrew; Hanlon, Alexandra et al. (2017) Perceived neighborhood safety related to physical activity but not recreational screen-based sedentary behavior in adolescents. BMC Public Health 17:722
Patterson, Freda; Zaslav, David S; Kolman-Taddeo, Diana et al. (2017) Smoking Cessation in Pulmonary Care Subjects: A Mixed Methods Analysis of Treatment-Seeking Participation and Preferences. Respir Care 62:179-192
Wenner, Megan M; Sebzda, Kelly N; Kuczmarski, Andrew V et al. (2017) ETB receptor contribution to vascular dysfunction in postmenopausal women. Am J Physiol Regul Integr Comp Physiol 313:R51-R57
Nair, Uma S; Patterson, Freda; Rodriguez, Daniel et al. (2017) A telephone-based intervention to promote physical activity during smoking cessation: a randomized controlled proof-of-concept study. Transl Behav Med 7:138-147
Wright, Regina S; Gerassimakis, Constance; Bygrave, Desirée et al. (2017) Dietary Factors and Cognitive Function in Poor Urban Settings. Curr Nutr Rep 6:32-40
Perkett, Mackenzie; Robson, Shannon M; Kripalu, Varsha et al. (2017) Characterizing Cardiovascular Health and Evaluating a Low-Intensity Intervention to Promote Smoking Cessation in a Food-Assistance Population. J Community Health 42:605-611

Showing the most recent 10 out of 18 publications