The purpose of the Alteration and Renovation plan is to provide a Strategic Administrative, Conferencing & Scientific (SACS) facility in support of the goals of the Autophagy, Inflammation and Metabolism Center (AIM) Center for integrated research on autophagy, inflammation and metabolism in a broad spectrum of diseases in alignment with the priorities of the signature programs at our Institution. The goals of the SACS Alteration and Renovation plan are: First, to transform the space committed by the UNM HSC into an effective Scientific Core (SCICORE) facility that will co-house the two scientific cores (Autophagy scientific core, ASC; and Inflammation and Metabolism Core, IMC). Second, to develop a strategic meeting (conference room) and collaborative/training (AIM laboratory;
AIM LAB) work space to support missions of the Center, where investigators engaged in diverse fields will find a common interest in studying connections between autophagy, inflammation and metabolism in a variety of diseases. Third, to provide centralized administrative space that supports the Center and its scientific, mentoring, evaluative and fiscal activities (Administrative core; AC). Together, these components comprise a unified SACS facility. The laboratories and offices of the Program Director, the majority of the mentored PIs, and the key investigators in the Scientific Cores are located in the SACS immediate area, one floor below, or in adjacent buildings connected by short bridges or walkways, with SACS being physically located in the center as a hub. Renovation of laboratory space is necessary for the establishment of the two new Scientific Cores, ASC and IMC. These renovations will be located in space with close proximity to a large open laboratory space (AIMLAB) that was recently remodeled using institutional funds and is committed to AIM.
The AIM LAB space will provide bench space for investigators using the Cores, as well as space for training and workshops presented by the Cores.
The AIM conference room (Center Meeting Hub) will provide space for internal presentations, reviews and assessment and will support collaborations inside the institution and with outside consultants and research and administrative partners. The centralized SACS space will promote an institutional identity for the Center and help achieve recognition in the broader scientific community.
The goal of the AIM Center is the integration of research in autophagy, inflammation and metabolism to develop insights into mechanisms of chronic inflammatory and metabolic diseases. The alterations and renovations described here will provide the essential improvements that together with existing institutional resources will support the pioneering research needed to achieve the Center's goals.
| Tasnim, Humayra; Fricke, G Matthew; Byrum, Janie R et al. (2018) Quantitative Measurement of Naïve T Cell Association With Dendritic Cells, FRCs, and Blood Vessels in Lymph Nodes. Front Immunol 9:1571 |
| Castillo, Eliseo F; Zheng, Handong; Yang, Xuexian O (2018) Orchestration of epithelial-derived cytokines and innate immune cells in allergic airway inflammation. Cytokine Growth Factor Rev 39:19-25 |
| Zheng, Handong; Wu, Dandan; Wu, Xiang et al. (2018) Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway. Sci Rep 8:8905 |
| Deretic, Vojo; Klionsky, Daniel J (2018) Autophagy and inflammation: A special review issue. Autophagy 14:179-180 |
| Zhang, Xing; Luo, Yan; Wang, Chunqing et al. (2018) Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway. Cell Rep 24:3180-3193 |
| Kumar, Suresh; Jain, Ashish; Farzam, Farzin et al. (2018) Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins. J Cell Biol 217:997-1013 |
| Claude-Taupin, Aurore; Bissa, Bhawana; Jia, Jingyue et al. (2018) Role of autophagy in IL-1? export and release from cells. Semin Cell Dev Biol 83:36-41 |
| Deretic, Vojo; Levine, Beth (2018) Autophagy balances inflammation in innate immunity. Autophagy 14:243-251 |
| Jia, Jingyue; Abudu, Yakubu Princely; Claude-Taupin, Aurore et al. (2018) Galectins Control mTOR in Response to Endomembrane Damage. Mol Cell 70:120-135.e8 |
| Choi, Seong Won; Gu, Yuexi; Peters, Ryan Scott et al. (2018) Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity. Antimicrob Agents Chemother 62: |
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