The NCCU EXPORT Center will establish Shared Resources Cores that will support research being conducted by the three Research Core Components: Cardiovascular Disease, Substance Abuse and Addition, and Cancer Research. A Genomics core will be developed and through the acquisition of new equipment will provide a variety molecular biologic methods including moderate throughput candidate gene polymorphism analysis and gene sequencing. A Bioinformatics core will be established in collaboration with scientists from the DUMC Center for Human Genomics and will provide general statistical support for the EXPORT Center and specialize in statistical genetics including the complex analysis of phenortype and genotype data derived from large population studies. The Animal Resource and Transgenic Genotyping facility will focus on providing a state of the art program for the breeding and genotyping of a variety of transgenic animals including knockout mouse strains and cogenic rat strains. The Genomics and Animal Resource and Transgenic Genotyping Cores will be directed by existing JLCBBRI scientists while the Director of the Bioinformatics core will be recruited to NCCU using EXPORT resources. The Directors will ensure that quality assurance activities are in place, provide continual evaluation of the operation and resource needs and will collaborate on EXPORT research projects. In addition to providing support to the research cores, the Shared Resources Cores will enhance the JLCBBRI's research training capabilities by providing opportunities for NCCU students to participate in mentored laboratory training/experiences with projects focused on minority health disparities. The Shared Resources Cores will also contribute to the research and training efforts undertaken by the EXPORT Center's Partnerships with Duke Unievrsity Medical Center, the University of North Carolina at Chapel Hill, and the Wake Forest University School of Medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
1P20MD000175-01
Application #
6695252
Study Section
Special Emphasis Panel (ZMD1)
Project Start
2002-09-30
Project End
2007-09-29
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost
Name
North Carolina Central University
Department
Type
DUNS #
072026321
City
Durham
State
NC
Country
United States
Zip Code
27707
Choi, Sora; Neequaye, Prince; French, Samuel W et al. (2018) Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice. J Biol Chem 293:1-17
Wilkins, Jeffrey; Ghosh, Palash; Vivar, Juan et al. (2018) Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005-2008. BMC Obes 5:21
Dubey, Bhawna; Jackson, Maria D; Zeigler-Johnson, Charnita et al. (2017) Inflammation polymorphisms and prostate cancer risk in Jamaican men: Role of obesity/body size. Gene 636:96-102
Pointer, Mildred A; Hicks, Kianda; Williams-Devane, ClarLynda et al. (2015) Gender differences in preclinical markers of kidney injury in a rural north Carolina african-american cohort. Front Public Health 3:7
Pointer, Mildred A; Eley, Shaleka; Anderson, Lauren et al. (2015) Differential Effect of Renal Cortical and Medullary Interstitial Fluid Calcium on Blood Pressure Regulation in Salt-Sensitive Hypertension. Am J Hypertens 28:1049-55
Ghosh, Sujoy; Vivar, Juan; Nelson, Christopher P et al. (2015) Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol 35:1712-22
Sesay, John S; Gyapong, Reginald N K; Najafi, Leila T et al. (2015) G?i/o-dependent Ca(2+) mobilization and G?q-dependent PKC? regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Neurochem Int 90:142-51
Rankinen, Tuomo; Sarzynski, Mark A; Ghosh, Sujoy et al. (2015) Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors? Circ Res 116:909-22
Spruiell, Krisstonia; Gyamfi, Afua A; Yeyeodu, Susan T et al. (2015) Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther 354:459-70
Chatterjee, Pradeep K (2015) Directing enhancer-traps and iTol2 end-sequences to deleted BAC ends with loxP- and lox511-Tn10 transposons. Methods Mol Biol 1227:99-122

Showing the most recent 10 out of 59 publications