UTB/TSC is a minority community institution emerging as the biomedical research center within the rapidlyexpanding lower Rio Grande valley. A research infrastructure to support biomedical researchers is currentlybeing build. To supplement and enhance research programs the gola of this application is two-fold: (1) Todevelop a core facility that will effectively meet, enhance and support the research needs of faculty, enhancethe research learning experiences of students, and provide greater opportunity for collaborative researchprojects addressing specific health needs of medically underserved minority populations between UTB/TSCresearchers and students, and faculty at other research intensive universities. (2) to demonstrate to facultyhow global genomic/proteonomic data can be effectively utilized, incorporated and thus enhance and widenthe scope of currently existing research projects, by acquiring preliminary data that can be utilized in futuregrant applications.
The specific aims of this application are: 1 .To acquire instrumentation for a core facility toprovide proteonomic and genomic capabilities 2.To enhance existing faculty research programs by bringingmodern genomic/proteonomics capabilities to UTB/TSC 3.To introduce and instruct our students in the useof state-of-the-art research tools and methods 4.To enhance the opportunities of our faculty and students todevelop critical and meaningful collaborative and multidisciplinary research collaborations 5. To providetechnical staff to ensure that the core facility is available and to provide technical assistance to our facultyand students for their research projects. 6. To generate preliminary genomics/proteonomics data forUTB/TSC faculty that will broaden the scope and enhance the competiveness of their research programs. Toaccomplish these specific aims we propose to acquire microarray instrumentation, a real-time PCR machine,an electroporation system and equipment that allows for two-dimensional gel separation of complex proteinmixtures. The instruments will be housed in a newly constructed Analytical Molecular Biology Core Facility.
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