Abstract

The medial septum and diagonal bands (medial septal region) is a division of the basal forebrain that is? affected by aging and in particular by Alzheimer's disease. The medial septal region contains a? heterogeneous population of neurons, including cholinergic and non-cholinergic projection neurons and? interneurons. Even though inputs from septal neuronal populations are necessary for the normal processing? of information by hippocampal and neocortical networks, only fragmented information on the anatomy,? electrophysiology and pharmacology of most septal neuronal populations (cholinergic cells are the? exception) is currently available. In addition, the connectivity of septal neuronal populations and their? alteration with aging is fundamentally unknown. This proposal is dedicated to identify synaptic connections? among septal neurons, the functional circuits established through these connections and the aging effect on? septal synaptic connectivity. The proposed experiments will facilitate the modeling of normal and age-altered? septal connectivity. They also may result in therapeutic strategies dedicated to modulate cognitive processes? and alleviate the burden of age-related disorders, in particular Alzheimer's disease. The experimental? strategy delineated in this proposal will also provide strong opportunities for intra- and inter-institutional? collaborations and new career development opportunities for UTB/TSC faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD001091-02
Application #
7547677
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2005-11-01
Budget End
2006-10-31
Support Year
2
Fiscal Year
2006
Total Cost
$169,492
Indirect Cost

  Institution

Name
University/Texas Brownsville & Southmost Coll
Department
Type
DUNS #
800187965
City
Brownsville
State
TX
Country
United States
Zip Code
78520

  Publications

Unterweger, Daniel; Miyata, Sarah T; Bachmann, Verena et al. (2014) The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition. Nat Commun 5:3549
Cox, N; Toro, B; Pacheco-Otalora, L F et al. (2014) An endoplasmic reticulum trafficking signal regulates surface expression of ?4 subunit of a voltage- and Ca²?-activated K? channel. Brain Res 1553:12-23
Gonzales, Miguel F; Brooks, Teresa; Pukatzki, Stefan U et al. (2013) Rapid protocol for preparation of electrocompetent Escherichia coli and Vibrio cholerae. J Vis Exp :
Ermolinsky, Boris; Peredelchuk, Michael; Provenzano, Daniele (2013) ?-Cyclodextrin decreases cholera toxin binding to GM1-gangliosides. J Med Microbiol 62:1011-4
Upreti, Chirag; Otero, Rafael; Partida, Carlos et al. (2012) Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy. Brain 135:869-85
Wein, Alexander N; Williams, Brian N; Liu, Shihui et al. (2012) Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization. J Med Chem 55:7998-8006
Unterweger, Daniel; Kitaoka, Maya; Miyata, Sarah T et al. (2012) Constitutive type VI secretion system expression gives Vibrio cholerae intra- and interspecific competitive advantages. PLoS One 7:e48320
Garrido-Sanabria, Emilio R; Perez-Cordova, Miriam G; Colom, Luis V (2011) Differential expression of voltage-gated K+ currents in medial septum/diagonal band complex neurons exhibiting distinct firing phenotypes. Neurosci Res 70:361-9
Oliveira, Mauro Schneider; Pacheco, Luis Fernando; Mello, Carlos Fernando et al. (2011) Epileptiform activity in the limbic system. Front Biosci (Schol Ed) 3:565-93
Ermolinsky, Boris S; Skinner, Frank; Garcia, Ileana et al. (2011) Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy. Neurosci Res 69:73-80

Showing the most recent 10 out of 24 publications