Prostate cancer is the second leading of cancer deaths among american men after skin cancer. In African- American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate due to this disease in African-American are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development at Clark Atlanta University is building a comprehensive research program to investigate the cellular and genetic factors involved in transformation, angiogenesis and metastasis of prostate cancer and how these factors may differ in African- American men. Three research projects in this grant application will investigate 1. Role of TGFbeta signaling during different phases of prostate cancer, 2. Impact of androgen regulated immune/inflammatory pathways in prostate cancers, and 3. The role of SNAIL transcription factor and TGFbeta in bone metastasis of prostate cancer cells. In addition, we are proposing six pilot projects which will focus on different aspects of prostate cancer biology such as: the role of IL-10 in prostate cancer immunity, c-kit ligand and signaling in metastatic cancer cells, role of PI3-kinase isoforms in prostate cancer, chromatin remodeling and its impact in prostate cancer cells, role of sterols in prostate cancer cell proliferation and apoptosis, and development of highly sensitive techniques to detect prostate cancer biomarkers. All investigators are housed in the same building and have access to state-of- the Art research core laboratories. These cores provide instrumentation and technical assistance in cell biology, molecular biology, and imaging. These facilites are managed by a Senior Research Scientist and a Facilites Coordinator. The reagents, clinical samples and materials generated for individual projects will be handled by the research core and will be shared by all investigators. The research projects from individual investigators are based on very interactive approaches and provide opportunities for collaborations among multiple investigators at the Center and scientists at several other institutions. The Pis of different projects and the research staff meets once a week to monitor and discuss the progress of individual projects and the scientific program of the center is overseen by external advisory committees with several members in the area of prostate cancer biology and chemistry.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD002285-05
Application #
8296100
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
2012-09-04
Budget Start
2011-07-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2011
Total Cost
$215,062
Indirect Cost
Name
Clark Atlanta University
Department
Type
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314
Elliott, Bethtrice; Zackery, DeAdra L; Eaton, Vanessa A et al. (2018) Ethnic differences in TGF?-signaling pathway may contribute to prostate cancer health disparity. Carcinogenesis 39:546-555
Kimbrough-Allah, Mawiyah N; Millena, Ana C; Khan, Shafiq A (2018) Differential role of PTEN in transforming growth factor ? (TGF-?) effects on proliferation and migration in prostate cancer cells. Prostate 78:377-389
Scarlett, Kisha A; White, El-Shaddai Z; Coke, Christopher J et al. (2018) Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits G?13/RhoA-mediated Migration. Mol Cancer Res 16:728-739
Caggia, Silvia; Chunduri, HimaBindu; Millena, Ana C et al. (2018) Novel role of Gi?2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol 234:802-815
Hawsawi, Ohuod; Henderson, Veronica; Burton, Liza J et al. (2018) High mobility group A2 (HMGA2) promotes EMT via MAPK pathway in prostate cancer. Biochem Biophys Res Commun 504:196-202
Burton, Liza J; Henderson, Veronica; Liburd, Latiffa et al. (2017) Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1. Biochem Biophys Res Commun 491:59-64
Morton, Derrick J; Patel, Divya; Joshi, Jugal et al. (2017) ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget 8:2536-2549
Barrett, Cachétne S X; Millena, Ana C; Khan, Shafiq A (2017) TGF-? Effects on Prostate Cancer Cell Migration and Invasion Require FosB. Prostate 77:72-81
Joshi, Jugal Bharat; Patel, Divya; Morton, Derrick J et al. (2017) Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol 11:337-357
Yu, Min; Wang, Ulrica; Wang, Zhengxin (2016) E2F and GATA switches turn off WD repeat domain 77 expression in differentiating cells. Biochem J 473:2331-43

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