Cardiovascular (CV) disease remains the leading cause of death in this country and the City of Boston, (ref) Of concern, there is compelling evidence that a disproportionate share of the burden of CV disease, and metabolic/vascular risk factors falls on racial and ethnic minorities. [1] [3, 4] Eliminating these disparities is a national and local health priority;and adequate access to culturally appropriate, clinically effective preventive cardiovascular services is important to achieve this goal, (ref) The trend for individuals to have multiple risk factors is increasing[5] and although weight loss and lifestyle interventions have been shown to modify metabolic/vascular abnormalities and CVD risk factors, [3] [6-8] prevalence estimates of these conditions continue to increase, particularly for African Americans.[5] The barriers to effective risk factor reduction are multifactorial, including individual biopsychosocial and environmental factors.[9, 10] The high prevalence of African Americans with known multiple risk factors for CAD, the evidence that modifying risk factors can prevent or modify these conditions and the fact that barriers to effective risk factor reduction are multifactorial, suggests that prevention and risk factor reduction efforts should focus on comprehensive risk reduction strategies in this at-risk group. [5] Our team will test the feasibility of conducting a randomized, non-blinded,'parallel-group, study to assess the outcome of a community based, multiple risk factor diabetes prevention program in an at-risk African American community (Roxbury). The primary aims of the study are to demonstrate the feasibility of recruiting and retaining African American adults to this randomized trial and to describe changes in weight and waist circumference as well as behavioral, psychosocial and physiological endpbints. Recruitment in randomized clinical trials can be difficult in the African American community because of mistrust. This trial arises from several years of community partnership in the community of interest and builds on the trust established in this clinical work. In addition, little is known about the effectiveness, in underserved communities, of communitybased, culturally appropriate, multiple risk reduction interventions. Successful implementation of a community based multiple risk factor reduction program in this underserved and at-risk community has implications for practice and policy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD002290-04
Application #
8077397
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
4
Fiscal Year
2010
Total Cost
$16
Indirect Cost
Name
University of Massachusetts Boston
Department
Type
DUNS #
808008122
City
Boston
State
MA
Country
United States
Zip Code
02125
Ravenelle, Rebecca; Berman, Ariel K; La, Jeffrey et al. (2018) Sex matters: females in proestrus show greater diazepam anxiolysis and brain-derived neurotrophin factor- and parvalbumin-positive neurons than males. Eur J Neurosci 47:994-1002
O'Brien, Kymberlee M; Meyer, Jerrold; Tronick, Edward et al. (2017) Hair cortisol and lifetime discrimination: Moderation by subjective social status. Health Psychol Open 4:2055102917695176
Mian, Nicholas D; Godoy, Leandra; Eisenhower, Abbey S et al. (2016) Prevention Services for Externalizing and Anxiety Symptoms in Low-Income Children: the Role of Parent Preferences in Early Childhood. Prev Sci 17:83-92
Mian, Nicholas D; Eisenhower, Abbey S; Carter, Alice S (2015) Targeted prevention of childhood anxiety: engaging parents in an underserved community. Am J Community Psychol 55:58-69
Cholanian, Marina; Lobzova, Anna; Das, Bhargab et al. (2014) Digital holographic microscopy discriminates sex differences in medial prefrontal cortex GABA neurons following amphetamine sensitization. Pharmacol Biochem Behav 124:326-32
Ravenelle, Rebecca; Neugebauer, Nichole M; Niedzielak, Timothy et al. (2014) Sex differences in diazepam effects and parvalbumin-positive GABA neurons in trait anxiety Long Evans rats. Behav Brain Res 270:68-74
Ravenelle, R; Santolucito, H B; Byrnes, E M et al. (2014) Housing environment modulates physiological and behavioral responses to anxiogenic stimuli in trait anxiety male rats. Neuroscience 270:76-87
Berman, Ariel Kupfer; Lott, Rhonda B; Donaldson, S Tiffany (2014) Periodic maternal deprivation may modulate offspring anxiety-like behavior through mechanisms involving neuroplasticity in the amygdala. Brain Res Bull 101:7-11
Godoy, Leandra; Mian, Nicholas D; Eisenhower, Abbey S et al. (2014) Pathways to service receipt: modeling parent help-seeking for childhood mental health problems. Adm Policy Ment Health 41:469-79
Eisenhower, Abbey; Suyemoto, Karen; Lucchese, Fernanda et al. (2014) ""Which box should I check?"": examining standard check box approaches to measuring race and ethnicity. Health Serv Res 49:1034-55

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